Recombinant Rat Tripeptidyl-peptidase 1 (Tpp1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Tpp1

Purity

>85% (SDS-PAGE)

Target Names

Tpp1

Uniprot NO.

Q9EQV6

Alternative Names

Tpp1; Cln2; Tripeptidyl-peptidase 1; TPP-1; EC 3.4.14.9; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I; TPP-I

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

196-563

Target Protein Sequence

LHLGV TPSVLRQRYN LTARDVGSGT TNNSQACAQF LEQYFHNSDL TEFMRLFGSS FAHQASVARV VGKQGRGRAG IEASLDVEYL MSAGANISTW VYSSPGRHEA QEPFLQWLLL LSNESSLPHV HTVSYGDDED SLSSVYIQRV NTEFMKAAAR GLTLLFASGD TGAGCWSVSG RHKFRPSFPA SSPYVTTVGG TSFKNPFLVT NEVVDYISGG GFSNVFPQPS YQEEAVAQFL KSSSHLPPSS YFNASGRAYP DVAALSDGYW VVSNMVPIPW VSGTSASTPV FGGILSLINE HRLLNGRPPL GFLNPRLYQQ HGAGLFDVTH GCHESCLNEE VEGQGFCSGP GWDPVTGWGT PNFPALLKTL LNP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.

Gene References into Functions

TPPI activity was strictly regulated following hypoxic stress in the rat brain. PMID:27263093
These findings also suggest that TPP I is involved in the general turnover of chemotransmitters between glomus cells and sensory nerve endings which emphasizes its importance for chemoreception under hypoxic conditions. PMID:25636608
We describe a molecular mechanism in which inducible interactions of noncanonical RNA motif structures with targeting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the basis for activity-dependent dendritic RNA targeting with CLN2. PMID:24841565

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Subcellular Location

Lysosome. Melanosome.

Database Links

UNIGENE: Rn.162472

KEGG: rno:83534

STRING: 10116.ENSRNOP00000026280

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