Recombinant Rat Transcription factor 12 (Tcf12)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Tcf12

Uniprot NO.

P51514

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-707

Target Protein Sequence

MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD HTSSSFPSNP STPVGSPSPL TAGTSQWPRA GGQAPSSPSY ENSLHSLKNR VEQQLHEHLQ DAMSFLKDVC EQSRMEDRLD RLDDAIHVLR NHAVGPSTSL PTSHSDIHSL LGPSHNAPIG NLNSNYGGSS LVTNSRSASM VGTHREDSVS LNGNHSVLSS TVAASNTELN HKTPESFRGG VQNQSGSVVP TEIKTENKEK DENLHEPPSS DDMKSDDESS QKDIKVSSRG RTSSTNEDED LNPEQKIERE KERRMANNAR ERLRVRDINE AFKELGRMCQ LHLKSEKPQT KLLILHQAVA VILSLEQQVR ERNLNPKAAC LKRREEEKVS AASAEPPTTL PGTHPGLSET TNPMGHL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Gene References into Functions

The learning and memory deficits in Tcf12 animals are likely due to neuropathology associated with Tcf12 gene expression. PMID:21982980
HEB is implicated in the development of skeletal muscle (HEB). PMID:15554944

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Subcellular Location

Nucleus.

Tissue Specificity

Isoform gamma is highly expressed in lung, kidney, spleen, and is expressed at reduced levels in heart, muscle, liver, pituitary, brain and the trigeminal ganglion. The expression of isoform alpha predominates over isoform gamma in the pituitary and the b

Database Links

UNIGENE: Rn.165133

KEGG: rno:25720

STRING: 10116.ENSRNOP00000023634

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