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Recombinant Rat Thyrotropin receptor (Tshr), partial

Recombinant Rat Thyrotropin receptor (Tshr), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Tshr

Uniprot NO.

P21463

Alternative Names

Tshr; Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Could you produce this item with N-terminal 6xHis tag and HEK293 cell ?
Thank you for your help.

Thanks for your inquiry.
Recombinant Rat Thyrotropin receptor(Tshr),partial
CSB-YP025131RA1 >> Yeast
CSB-EP025131RA1 >> E.coli
CSB-BP025131RA1 >> Baculovirus
CSB-MP025131RA1 >> Mammalian cell
Expression Region: 22-413aa; The extracellular domain.
Tag information: Tag type will be determined during the manufacturing process.
We can try your desired tag preferentially if you have, but as we can't 100% guaranteed, if it's failed, we will provide the protein with other tag.
The success rate of expressing the protein with your desired tag is 95.25%.
Target protein sequence: (The whole complete sequence will include tag sequene, target protein sequence and any linker sequence)

RGCTSPPCECHQEDDFRVTCKELHQIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMG

Yes, we can produce this protein with N-terminal 6xHis tag and HEK293 cell, pls remark your requirement when you place the order.

We are interested in your following product: Recombinant Rat Thyrotropin receptor(Tshr),partial
1. Could you please let us know the expression region and tag information of this product?
2. Please let us know the formulation and preservative information of this product.
Thank you for your support. Looking forward to hearing from you.

Thanks for your inquiry. Pls check the information as follows:
Recombinant Rat Thyrotropin receptor(Tshr),partial
CSB-YP025131RA1 >> Yeast
CSB-EP025131RA1 >> E.coli
CSB-BP025131RA1 >> Baculovirus
CSB-MP025131RA1 >> Mammalian cell
Expression Region: 22-413aa; The extracellular domain.
Tag information: Tag type will be determined during the manufacturing process.
We can try your desired tag preferentially if you have, but as we can't 100% guaranteed, if it's failed, we will provide the protein with other tag.
The success rate of expressing the protein with your desired tag is 95.25%.
Target protein sequence: (The whole complete sequence will include tag sequene, target protein sequence and any linker sequence)

The buffer formulation for this protein is Tris-based buffer, 50% glycerol.
Storage:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Target Background

Function(From Uniprot)

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

Gene References into Functions

Data suggest that functional thyroid-stimulating hormone receptor is present in the caudal brainstem and hypothalamic nuclei of relevance for feeding control as a possibly uncleaved holoreceptor, and highlights a hindbrain component to central thyroid-stimulating hormone inhibition of food intake. PMID:27059392
TSH signal transduction in cultured tanycytes signals via G alphas to increase cAMP via an alternative G protein to increase phosphorylation of ERK1/2. PMID:25878058
Results show that Tshr mRNA levels were up-regulated during differentiation of brown adipocytes. During the differentiation of brown adipocytes PMID:25662278
Higher TSH level in the BN strain appears to reflect an adjustment of the feedback loop to reduced thyrocyte sensitivity to TSH secondary to reduced TSHR expression. PMID:17640981
TSHR is present and functional in hepatocytes. PMID:19187127
Data indicate that the presence of thyrostimulin in the ovary suggests that it may have a primitive function in reproduction when it activates ovarian TSHR. PMID:19955180
Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats PMID:11755178
Identical amino acid residues in homologous receptors can exhibit distinct functions. Role of ionic strength (Na+) on signaling differs in the three receptors. PMID:12588044
mutation effects vary with the ambient iodide supply and could be masked in regions of high iodine intake PMID:15691889