Recombinant Rat Thy-1 membrane glycoprotein (Thy1)

1. THY1 is expressed in the anterior lobe of the rat pituitary gland.THY1 is a novel specific marker of thyrotropes, which produce TSH. PMID:27765629
2. Thymocyte antigen 1 (Thy-1) is a highly expressed cell-surface protein in lung fibroblasts, which plays a key role in fetal alveolarization by coordinating the differentiation and lipid homeostasis of alveolar lipid containing fibroblasts. PMID:24374733
3. first report that Thy1 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subunit protein. PMID:22281825
4. Study is the first to demonstrate a functional link between alphavbeta3 integrin and P2X7 receptors, and to reveal an important, hitherto unanticipated, role for P2X7 in calcium-dependent signaling required for Thy-1-stimulated astrocyte adhesion. PMID:21502139
5. Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts. PMID:20724553
6. The Thy1-GFP rat is a novel transgenic tool that enables direct visualization of facial nerve regeneration after injury. PMID:20855773
7. Thy-1 is a good marker for characterizing osteoprogenitor cells. PMID:20124093
8. Thy1 regulates fibroblast focal adhesions. cytoskeletal organization and migration through modulation of p190 RhoGap and Rho GTPase activity. PMID:15093746
9. Thy-1-induced morphological changes in astrocytes requires rhoA activation and integrin aggregation PMID:15220352
10. Thy-1 expression is developmentally regulated and is closely associated with the functional maturation of dorsal root ganglia neurons during both postnatal development and nerve regeneration PMID:15547945
11. Critical epitope detected by 1-22-3 in this study may play an important role in mesangial function and injury. PMID:15569310
12. We revealed that TCRalphabeta-dependent stages of T-cell development are affected by ageing, most likely due to an impaired expression of Thy-1 on TCRalphabeta(low) thymocytes entering selection processes. PMID:16632291
13. These data indicate that Thy-1 regulates myogenic gene expression, myofibroblastic differentiation, and survival in lung fibroblasts. PMID:16960126
14. results demonstrate that cardiac fibroblasts express Thy-1 and form a homogeneous population; Thy-1 expression also appears to be independent of fibroblast differentiation PMID:17395197
15. anti-Thy-1 antibody activates the c-Src kinase-MEK-cyclic AMP response-element binding protein cascade PMID:17486586
16. Enriched Thy-1(+) ED14 fetal liver cells proliferate and repopulate the liver only after extensive liver injury and represent a fetal hepatic progenitor cell population distinct from Thy-1(-) stem/progenitor cells, which repopulate the normal adult liver. PMID:17647294
17. Thy-1 is not a marker of oval cells but is present on a subpopulation of myofibroblasts/stellate cells. PMID:17884967
18. Thy-1(+) cells in the oval cell niche during liver regeneration are activated mesenchymal-epithelial cells that are distinct from resident stellate cells, myofibroblasts, and oval cells. PMID:19575449

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UNIGENE: Rn.108198

KEGG: rno:24832

STRING: 10116.ENSRNOP00000008685