Recombinant Rat Thrombospondin-4 (Thbs4), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Thbs4

Uniprot NO.

P49744

Alternative Names

Thbs4; Tsp-4; Tsp4Thrombospondin-4

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

43-980

Target Protein Sequence

QATPQVFD LLPSSSQRLN PAALQPVLTD PTLHELYVIS TFKLQSKSSA TIFGLYSSSD NSKYFEFTVM GRLNKAILRY LKDDGKIHLV VFNNLQLADG RRHRILLRLS NLQRGAGSVE LYLDCVQVDS VNNLPRAFSG LTQNPQAIEL RTFQRKPQDF LEELKLVVRG SLFQVASLQD CFLQQSEPLA ATGTGDFNRQ FLGQMTQLNQ LLGEVKDLLR QQVKETSFLR NTIAECQACG PLSFQSPTPN TLVPIAPPAP PTRPTRRCDS SPCFRGVRCT DTRDGFQCGP CPDGYTGNGI TCSDVDECKY HPCYPGVRCT NLAPGFRCDA CPVGFTGPMV QGVGINFAKT NKQVCTDVDE CRNGACVLNS ICINTLGSYR CGPCKPGYTG DQTRGCRTER SCRNPEQNPC SVHAQCIEER QGDVTCVCGV GWAGRAGYVC GKDVDIDSYP DEELPCSARN CKKDNCKYVP NSGQEDADRD GIGDACDEDA DGDGILNEQD NCVLTHNVDQ RNTDKDIFGD ACDNCRGVLN NDQKDTDGDG KGDACDDDMD GDGIKNILDN CPRVPNRDQQ DRDGDGVGDA CDSCPDVSNP NQSDVDNDLV GDSCDTNQDS DGDGHQDSTD NCPTVINSAQ LDTDKDGIGD ECDDDDDNDG MPDLFPPGPD NCRLVPNPAQ EDSNNDGVGD ICEADFDQDK VIDRIDVCPE NAEITLTDFR AYQTVVLDPE GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTQT DDDYAGFIFG YQDSSSFYVV MWKQTEQTYW QATPFRAVAE PGIQLKAVKS KTGPGEHLRN SLWHTGDTSD QVRLLWKDSR NVGWKDKVSY RWFLQHRPQV GYIRVRFYEG SELVADSGVT IDTTMRGGRL GVFCFSQENI IWSNLKYRCN DTIPEDFQEF QIQTFDRLDN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.

Subcellular Location

Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.

Protein Families

Thrombospondin family

Tissue Specificity

Mainly expressed in astrocytes, and in ressponse to peripheral nerve injury, significantly up-regulated in the dorsal spinal cord (at protein level).

Database Links

UNIGENE: Rn.11207

STRING: 10116.ENSRNOP00000062272

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