Home
Product
Protein
Recombinant Proteins
Recombinant Rat Telomerase reverse transcriptase (Tert), partial

Recombinant Rat Telomerase reverse transcriptase (Tert), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Tert

Purity

>85% (SDS-PAGE)

Target Names

Tert

Uniprot NO.

Q673L6

Alternative Names

Tert; Telomerase reverse transcriptase; EC 2.7.7.49; Telomerase catalytic subunit

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1125

Target Protein Sequence

MPRAPRCPAV RSLLRSRYRE VWPLATFVRR LGLEGSRLVQ PGDPKVFRTL VAQCLVCVPW GSQPPPADLS FHQVSSLKEL VSRVVQKLCE RGERNVLAFG FALLNGARGG PPMAFTTSVH SYLPNSVTES LCVSGAWMLL LSRVGDDLLV YLLSHCALYL LVPPSCAYQV CGSPLYQICA TTDTWSSVPA GYRPTRPVGG NFTNLGSAHQ IKNSGHQEAP KPQALPSRGT KRLLSLTSTN VPSAKKARFE PALRVDKGPH RQVVPTPSGK TWAPSPAASP KVPPAAKNLS LKGKASDPSL SGSVCCKHKP SSSSLLSSPP QDAEKLRPFT ETRHFLYSRG GGQEELNPSF LLNSLPPSLT GARRLVEIIF LGSRPRTSGP FCRTRRLPRR YWQMRPLFQQ LLMNHAKCQY VRFLRSHCRF RTANQRVPDA MDTSPSHLTS LLRLHSSPWQ VYGFLRACLR ELVPAGLWGT RHNERRFLKN VKKFISLGKY AKLSLQELMW RVKVEDCHWL RSSPEKDTVP AAEHRLRERI LAMFLFWLMD TYVVQLLRSF FYITETTFQK NRLFFYRKSV WSKLQSIGIR QQLERVQLRE LSQEEVKHHQ DTWLAMPICR LRFIPKLNGL RPIVNMSYGM DTRAFGKKKQ TQCFTQSLKT LFSVLNYERT KHPNLMGASV LGTSDSYRIW RTFVLRVRAL DQTPRMYFVK ADVTGAYDAI PQDKLVEIVA NIIRRSESMY CIRQYAVVQK DSQGQVHKSF RRQVSTLSDL QPYMGQFTKH LQDSDASALR NSVVIEQSIS MNETGSSLLH FFLRFVRHSV VKIDGRFYVQ CQGIPQGSSL STLLCSLCFG DMENKLFAEV QQDGLLLRFV DDFLLVTPHL AHAKAFLSTL VHGVPEYGCM INLQKTVVNF PVETGALGGA APHQLPAHCL FPWCGLLLDT RTLEVFCDYS GYGRTSIKMS LTFQGVSRAG KTMRYKLLSV LRLKCHGLFL DLQVNSLQTV CINIYKIFLL QAYRFHACVI RLPFGQHVRK NHAFFLGIIS NLASCCYAIL KVKNPGVSLR AKGAPGSFPP EATRWLCYQA FLLKLAAHSV TYKCLLGPLR TAQKQLCRKL PEATMTLLKT AADPALSTDF QTILD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

Gene References into Functions

Curcumin may be a good candidate to improve lifespan of rADSCs through promoting TERT gene expression. PMID:29017189
TERT was expressed in the basilar membranes during the first postnatal week. In vitro, TERT expression in progenitor cells reached a maximum at day 4 after culture and decreased as the culture time prolonged or the cell passage number increased. These results led us to hypothesize that TERT may be involved in the development of the cochlea and in maintaining the proliferation ability of progenitor cells. PMID:29436610
Proliferation rate, telomerase activity, telomere length, and differentiation to cholinergic neuron-like cells (CNLCs) were observed to increase. Though, the expression level of telomerase reverse transcriptase gene increased, but CTC1 and TEN1 genes from Ctc1-Stn1-Ten1 complex encoding proteins with regulatory function significantly decreased PMID:27251157
Histone deacetylase inhibition induces TERT transcription and promoter activation. At the protein level in contrast, HDAC inhibition decreases TERT protein abundance through enhanced degradation, which decreases telomerase activity and induces senescence. PMID:26505494
These findings suggest that cardiac telomerase activity may play an important role in the maintenance of normal cardiac function. PMID:25662949
TERT is a genome-independent source of mature miRNA, and the changes in telomerase activity can significantly influence the level of miRNA in cardiomyocytes. PMID:25156787
Elevated Hcy but not hypertension was related to TERT DNA hypomethylation and reduced mRNA level, thus contributing to the shortening of LTL hypertension. PMID:24882549
These data suggest that TERT plays a neuroprotective role via anti-apoptosis in neurons after oxygen and glucose deprivation PMID:23968592
hyperglycemia and hyperinsulinemia stimulate telomerase activity and the proliferation of vascular smooth muscle cells. PMID:23450462
Cadmium may contribute to carcinogenesis by activating telomerase, and overexpressing the mRNAs of TERT, c-myc and p53, and causing apoptosis of normal hepatocytes. PMID:21181359
TERT might function as an anti-apoptotic protein by inhibiting activation of caspase-3. PMID:22446191
Telomerase activation is present in ovary antral granulosa cells. PMID:21141566
The expression of TERT significantly increases after electrical stimulation of the cerebellar fastigial nucleus. TERT may bind to Bax and inhibit Bax-mediated apoptosis. PMID:21914402
p53 and telomerase control rat myocardial tissue response to hypoxia and ageing PMID:22073357
A role is found for telomerase in early cell senescence of olfactory ensheathing glia and protection from oxidative damage. PMID:20736004
TERT could be induced by hypoxia ischemia brain damage in neonatal rats, and might have a protective role in regulating cell apoptosis. PMID:20540267
Vascular injury induces de novo expression of TERT in intimal smooth muscle cells via activation of nuclear factor kappa B and upregulation of c-Myc,leading to hyperplasia. PMID:20864668
This study suggested that TERT deficiency can predispose to the development of stroke in an experimental model of this disease. PMID:20564349
TERT translocation might be more useful than TERT expression level and telomerase activity in predicting the progression of HCC. PMID:20353272
TGF-beta triggers cell cycle arrest and death by a mechanism involving telomerase deregulation of telomere maintenance. PMID:20138964
Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats. PMID:19855065
Results indicate that, in rat lung epithelial cells, in vitro transformation and acquisition of tumorigenic properties can occur even if telomere length is still decreasing and telomerase activity remains downregulated. PMID:12729792
telomerase, withdraws by a mechanism at TERT gene transcription level involving MAP kinase signalling while cells cease proliferation and undergo differentiation PMID:16248892
The results showed that inhibition of induced telomerase increased alpha-smooth muscle actin expression, an indicator of myofibroblast differentiation. PMID:16424384

Hide All

Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body.

Protein Families

Reverse transcriptase family, Telomerase subfamily

Tissue Specificity

Isoform 1 and isoform 2 expressed in thymus, liver, spleen, lung, kidney and testis. High level of inactive isoform 3 in adult hippocampus, low level in heart, cortex and cerebellum.

Database Links

UNIGENE: Rn.48802

KEGG: rno:301965

STRING: 10116.ENSRNOP00000022683

Promotions