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Recombinant Rat Tartrate-resistant acid phosphatase type 5 (Acp5)

Recombinant Rat Tartrate-resistant acid phosphatase type 5 (Acp5)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Acp5

Uniprot NO.

P29288

Alternative Names

Acp5; Tartrate-resistant acid phosphatase type 5; TR-AP; EC 3.1.3.2; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

23-327

Target Protein Sequence

APASTLRF VAVGDWGGVP NAPFHTAREM ANAKEIARTV QIMGADFIMS LGDNFYFTGV HDANDKRFQE TFEDVFSDRA LRNIPWYVLA GNHDHLGNVS AQIAYSKISK RWNFPSPYYR LRFKVPRSNI TVAIFMLDTV MLCGNSDDFV SQQPEMPRDL GVARTQLSWL KKQLAAAKED YVLVAGHYPI WSIAEHGPTR CLVKNLRPLL AAYGVTAYLC GHDHNLQYLQ DENGVGYVLS GAGNFMDPSV RHQRKVPNGY LRFHYGSEDS LGGFTYVEIG SKEMSITYVE ASGKSLFKTS LPRRPRP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates.

Gene References into Functions

increased osteoclast activity does not affect TRAP expression in osteoblasts and osteocytes PMID:24395179
Polyphosphate may play an important regulatory role in osteoclastic bone resorption by inhibiting TRAP activity. PMID:24223830
Data indicate that tartrate-resistant acid phosphatase 5b levels treated with cadmium and fluoride or in combination were 1-2.5 folds higher than the control. PMID:23868496
induction of TRAP provides an early sign of macrophage responsiveness in DSS induced colitis PMID:19821118
This study demonstrates that adhesion of isolated neonatal rat osteoclasts in vitro was augmented on bovine milk osteopontin (bmOPN) with post-translational modifications (PTMs) compared to human Escherichia-coli-derived recombinant OPN without PTMs. PMID:19854170
This enzyme is a useful serum marker for bone metastases in breast cancer patients. PMID:12820340
TRAP enzyme has a rapid turnover in osteoclasts and uses a transcytotic pathway PMID:14696961
The co-localization of PAP/TRAP and the cysteine protease cathepsin L could suggest a role for cathepsin L in the in vivo proteolytic processing of PAP/TRAP. proteolytic processing of PAP/TRAP PMID:15761664
Cathepsin K co-localized with TRAP in osteoclast-resorptive compartments, supporting a role for cathepsin K in the extracellular processing of monomeric TRAP in the resorption lacuna. PMID:15929988
insulin-dependent diabetes mellitus contributes to bone loss through changes in gene expression of TRAP and cathepsin K in osteoclasts as well as osteocalcin in osteoblasts PMID:17916452