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Recombinant Rat TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Tab2)

Recombinant Rat TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Tab2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Tab2

Purity

>85% (SDS-PAGE)

Target Names

Tab2

Uniprot NO.

Q5U303

Alternative Names

Tab2; Map3k7ip2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TGF-beta-activated kinase 1-binding protein 2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-693

Target Protein Sequence

MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS RTLTHSVSDG QLQGGQSNNE LFQQEPQTAP AQVPQGFNVF GMPSTSGASN STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT LAPNIQTGRS TPTSLHIHGV PPPVLNSPQG NSIYIRPYIT TPSGAARQTQ QHSGWVSQFN PVNPQQAYQP SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTVHS SASSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS TSSLVNSQTL NRNQPTVYIA ASPPSTDEMI SRSQPKVYIS ANASTGDEQG MRNQPTLFIS TNSGASAASR NMSGQVSMGP AFIHHHPPKS RVLGGNSAAS PRVVVTQPNT KYTFKITVSP NKPPAVSPGV VSPTFELTNL LNHPDHYVET ETIQHLTDPT LAHVDRVSEA RKLSMGSDDA AYTQALLVHQ KARMERLQRE LEMQKKKLDK LKSEVNEMEN SLTRRRLKRS NSMSQIPSLE EMQQLRSCNR QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS TIKAPKTQDT EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.

Subcellular Location

Membrane; Peripheral membrane protein. Cytoplasm, cytosol.

Database Links

UNIGENE: Rn.231700

KEGG: rno:308267

STRING: 10116.ENSRNOP00000021904

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