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Recombinant Rat Synaptonemal complex protein 3 (Sycp3)

Recombinant Rat Synaptonemal complex protein 3 (Sycp3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Sycp3

Purity

>85% (SDS-PAGE)

Target Names

Sycp3

Uniprot NO.

Q63520

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-257

Target Protein Sequence

MLRGCGEVGA VDCSPEQLNK HLKMVPGGRK HSGKSGKPPL IDQPKKAFDF EKEDKDLSGS EEDAVDEKTQ VFDKHGKKRS AGIIEDVGGE VQNMLEKFGA DINKALLAKK KRIEMYTKAS FKASNQKIEQ IWKTQQEEIQ KLNNEYSQQF LSVLQQWELD MQKFEEQGEK LTNLFRQQQK IFQQTRIVQS QRMKAIKQLH EQFIKSLEDV EKNNDNLFTG TQSELKKEMA MLQKKVMMET QQQEMANVRK SLQSMLF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.

Gene References into Functions

Unlike other vertebrates, rat and mouse SYCP3 exists in 2 isoforms; the short isoform is conserved in vertebrates and the longer isoform, appeared 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch. PMID:20339291
The possible contribution of different SYCP3 domains to the assembly of higher order structures, is investigated. PMID:18391527

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Subcellular Location

Nucleus. Chromosome. Chromosome, centromere.

Protein Families

XLR/SYCP3 family

Tissue Specificity

Detected in spermatocytes and testis (at protein level). Testis-specific.

Database Links

UNIGENE: Rn.34889

KEGG: rno:25561

STRING: 10116.ENSRNOP00000007088

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