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Recombinant Rat Sodium/glucose cotransporter 2 (Slc5a2), partial

Recombinant Rat Sodium/glucose cotransporter 2 (Slc5a2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Slc5a2

Uniprot NO.

P53792

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Gene References into Functions

These data suggest that SGLT2 is expressed in rat mesangial cells, acts as a normal physiological glucose sensor and regulates cellular contractility in rat mesangial cells. PMID:26999015
Sglt2 inhibition does not attenuate disease progression in the rat remnant kidney model of chronic kidney disease. PMID:26741142
By improving hyperglycemia and promoting weight reduction, SGLT2 inhibitor ipragliflozin may prove useful in treating type 2 diabetes in obese individuals. PMID:24486393
Data suggest that contribution of Sglt2 to renal glucose reabsorption is greater under hyperglycemia than under hypoglycemia; as hypoglycemic agents, Sglt2-selective inhibitors carry a lower risk of causing hypoglycemia than Sglt1 inhibitors. PMID:23249697
The inhibition of SGLT2 by phlorizin prevents the hyperglycemia and oxidative stress in kidney of diabetic rats, suggesting a prooxidative mechanism related to SGLT2 activity PMID:23227274
analysis of SGLT2 inhibitors containing the 1,2,3-triazole motif and evaluation of their urinary glucose excretion PMID:22079028
Evaluation of the effect of losartan on blood pressure and SGLT2 expression in diabetic rats with high or normal salt diet. PMID:19800706
in renovascular hypertension, angiotensin II induced SGLT2 via the AT1 receptor, which was evidenced at both the functional and expression levels, probably contributing to increased absorption of Na+ and thereby to the development of hypertension. PMID:14506074
HNF-1alpha, as a modulator of SGLT2 expression, may be involved in diabetic kidney disease PMID:17962340
Data show that SGLT2 levels in diabetic obese rats were 4.8 folds higher than age-matched leans, respectively. PMID:19095325
The downregulation of SGLT2 activity during STZ-induced diabetes may be a protective mechanism to control the excess of circulating glucose and could be a consequence of a decrease in SGLT2 expression in D3 and D7 PMID:19390222