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Recombinant Rat Signal transducer and activator of transcription 5B (Stat5b)

Recombinant Rat Signal transducer and activator of transcription 5B (Stat5b)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Stat5b

Uniprot NO.

P52632

Alternative Names

Stat5b; Signal transducer and activator of transcription 5B

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-786

Target Protein Sequence

MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRLEHLC QQLPIPGPVE EMLAEVNATI TDIISALSTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFDSQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFRE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS SSNHLEDYNS MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCER ATAKAADGYV KPQIKQVVPE FVNASTDAGS GATYMDQAPS PVVCPQAHYN MYPQNPDSVL DTDGDFDLED TMDVARRVEE LLGRPMDSQW IPHAQS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.

Gene References into Functions

Combinatorial interplay among multiple Stat5b-binding response elements with distinguishable biochemical properties is responsible for highly regulated control of IGF-I gene activity by growth hormone. PMID:23185594
STAT5b plays an essential role in growth hormone signaling activation and osteoblast differentiation. PMID:23071812
the inhibition of Stat5b expression in chondrocytes prevented the GH promoting effects on NF-kappaB-DNA binding, whereas the inhibition of NF-kappaB p65 expression or activity prevented the GH-dependent activation of IGF-1 and bmp2 expression. PMID:21592969
GH stimulates recruitment of Stat5b to multiple dispersed regions within the IGFI locus PMID:20378540
Insulin-like growth factor-I gene transcription is controlled by growth hormone through this protein PMID:12682066
EGF induces tyrosine phosphorylation and DNA-binding activity of Stat5b in a manner different from GH and PRL, apparently by a Src-dependent mechanism PMID:12767047
two intronic Stat5 DNA elements were able to bind Stat5b in vitro after GH treatment and could transmit GH- and Stat5b-dependent transcriptional responsiveness to the major IGF-I promoter PMID:14532269
These results, in addition to establishing STAT5b as one of the key agents of GH-stimulated gene transcription, demonstrate the feasibility of using in vivo gene transfer to target the functions of hormone-activated signal transduction pathways. PMID:14761873
phosphorylated Stat5b protein increases upon EPO stimulation in Leydig cells PMID:15062567
The activation of STAT5B by prolactin was biphasic, with an initial peak within 30 min, a nadir between 1 and 3 h, and prolonged activation after 4 h, in contrast, the response to growth hormone was transient for 1 h. PMID:15142985
growth hormone, via the coordinated action of HNFs and STAT5b, regulates sexually dimorphic liver gene expression [review] PMID:15253383
Stat5b A630P mutant is an inactive transcription factor by virtue of its aberrant folding and diminished solubility triggered by a misfolded SH2 domain. PMID:16303763
specific Stat5b binding sites mediate growth hormone-stimulated IGF-I gene transcription PMID:16339156
STAT-5B/STAT-3/Hsp27/FGF-2 signaling via its involvement in the regulation of vascular smooth muscle growth growth and motility may play an important role in the pathogenesis of vascular disease. PMID:16527988
around the end of pregnancy, prolactin loses the ability to activate STAT5b PMID:16857756
suppressor of cytokine signaling 2 is a direct signal transducer and activator of transcription 5b target in liver PMID:17008382
The cellular actions of GH normally mediated by activation of the Jak2/Stat5B pathway are suppressed in female cells. PMID:17332060
Immuno-blot analysis revealed the highest nuclear level of STAT5b in the fetus and during postnatal development, whereas in the adult it decreased. PMID:17565389
STAT2/5a/5b/6 were confirmed to be significantly modulated during focal cerebral ischaemia. PMID:17880360