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Recombinant Rat Signal transducer and activator of transcription 5A (Stat5a)

Recombinant Rat Signal transducer and activator of transcription 5A (Stat5a)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Stat5a

Purity

>85% (SDS-PAGE)

Target Names

Stat5a

Uniprot NO.

Q62771

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-793

Target Protein Sequence

MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRGQATQL LEGLVQELQK KAEHQVGEDG FVLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNCSSPA GVLVDAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL RIQAQFGQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELV EKHQKTLQLL RKQQTIILDD ELIQWKRGQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNR RSNHLEDYNS MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVFA KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGANATYM DQAPSPVVCP QAHYNMYPPN PDPVLDQDGE FDLDETMDVA RHVEELLRRP MDSLDPRLSP PAGLFTSARS SLS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

Gene References into Functions

found that phosphorylated STAT5 was expressed in almost all oxytocin neurones of late-pregnant and lactating rats but was almost absent from oxytocin neurones of virgin rats. PMID:26670189
STAT3/miR-211/STAT5A signaling plays a key role in mesenchymal stem cell migration. PMID:27145179
Findings define a novel molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling. PMID:22125600
Data show that STAT5 responsiveness to prolactin is enhanced by reproductive experience in multiple hypothalamic regions. PMID:21363933
Nuclear translocation of STAT5 can be used as a marker of prolactin receptor activation in hypothalamic dopaminergic neurons PMID:11406124
the 3'-UTR element reduced GH activation of a CYP2C12-luciferase construct harboring the 5'-Stat5 elements and speculate that binding of Stat5beta to the 3'-UTR element could be of relevance for the GH-dependent and sex-specific expression of CYP2C12. PMID:12089354
Activated Stat5a has a role in mammary gland cancer development in the rat and human. PMID:15609129
Results suggest that prolactin targets neurones of the supraoptic nucleus, influencing both activation of the JAK-STAT signalling pathway and neuronal excitability. PMID:15855883
Vitamin A-deficient diet results in serine-phosphorylated STAT5 accumulation in the liver. PMID:15963505
A significant increase in phosphorylated STAT5 was detected in the arcuate nucleus of female rats compared with same-sex controls after prolactin treatment PMID:16110263
STAT5A is modified with O-GlcNAc but is not Tyr-phosphorylated in hairless rats PMID:16227201
during lactation, STAT5 signaling is reduced and CIS is upregulated in tuberoinfundibular dopaminergic neurons PMID:16357045
Here we report for the first time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus. PMID:17353091
STAT2/5a/5b/6 were confirmed to be significantly modulated during focal cerebral ischaemia. PMID:17880360
ICA512 is a regulator of cyclins D and beta-cell proliferation through STAT3 and STAT5 PMID:18178618
Methylprednisolone upregulates the expression of bcl-XL via a direct binding of the GR/STAT5 complex on the putative STAT5-binding site. PMID:19228956
analysis of in vivo binding of STAT5 to growth hormone-regulated genes PMID:19423653