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Recombinant Rat Serine/threonine-protein kinase receptor R3 (Acvrl1), partial

Recombinant Rat Serine/threonine-protein kinase receptor R3 (Acvrl1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Acvrl1

Uniprot NO.

P80203

Alternative Names

Acvrl1; Acvrlk1; Serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Is this product a monomeric ALK1 protein?

For CSB-EP001262RA1, it is a semi-custom protein currently, so it is uncertain whether it is a monomeric ALK1 protein in the end. But as the protein has multiple disulfide bonds, there may be a polymer structure theoretically.

Target Background

Function(From Uniprot)

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Gene References into Functions

Increased expression of ALK-1 in the pulmonary vasculature of congenital diaphragmatic hernia (CDH) suggest that ALK-1 may play a crucial role in the molecular pathogenesis of vascular remodeling in CDH. PMID:26540443
Overexpression of Alk-5 and silencing of Alk-1 led to a loss of the chondrocyte phenotype, proving that they are key regulators of chondrocyte mechanosensing. PMID:25424912
ALK-1, an orphan receptor in the TGF-beta family, is a potential receptor for BMP-9 PMID:15851468

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Tissue Specificity

Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of e

Database Links

UNIGENE: Rn.10631

KEGG: rno:25237

STRING: 10116.ENSRNOP00000008673

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