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Recombinant Rat STE20-related kinase adapter protein alpha (Strada)

Recombinant Rat STE20-related kinase adapter protein alpha (Strada)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Strada

Purity

>85% (SDS-PAGE)

Target Names

Strada

Uniprot NO.

Q7TNZ6

Alternative Names

Strada; Lyk5; Strad; STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-393

Target Protein Sequence

MSFLANEASS ESIASFSKPE IMSSFLPEGG CYELLSVIGK GFEDLMTVNS RYKPTGEYVT VRRINLEACS NEMVTFLQGE LHVSKLFSHP NIVPYRATFI ADNELWAVTS FMAYGSAKDL IGTHFMDGMS ELAIAYILQG VLKALDYIHH MGYVHRSVKA SHILISTDGK VYLSGLRSNL SMISHGQRQR AVHDFPKYSI KVLPWLSPEV LQQNLQGYDA KSDIYSVGIT ACELANGHVP FKDMPATQML LEKLNGTVPC LLDTSTIPAE ELTMSPSRSI ANPGLNDSLA AGSLRPANGD SPSHPYHRTF SPHFHNFVEQ CLQRNPDARP NASTLLNHSF FKQIKRRASE ALPELLRPVT PITSFEGSQS QDHSGILGLV TNLEDLEVDD WEF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene References into Functions

local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation [STRAD protein] PMID:17482549
LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK. PMID:18687677

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Tissue Specificity

Expressed in liver.

Database Links

UNIGENE: Rn.11563

KEGG: rno:303605

STRING: 10116.ENSRNOP00000011894

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