Recombinant Rat SHC-transforming protein 1 (Shc1)

1. inactivation of the adaptor protein p66Shc decreases afferent arteriolar KATP channel activity and decreases renal damage in diabetic salt-sensitive rats. PMID:30131395
2. Our studies revealed that Coenzyme Q10 strongly inhibits nicotine-mediated production of reactive oxygen species and consequent apoptosis that requires serine36 phosphorylation but not mitochondrial translocation/cytochrome c binding of p66(shc). PMID:27770269
3. a pivotal role for p66(shc) -induced vascular dysfunction in a common pathogenic cascade shared by noise-induced and age-related hearing loss, is reported. PMID:27157635
4. Data suggest that, in a renal proximal tubule cell line, p66shc plays dual roles in promoting toxic effects of high-concentration of alpha-tocopherol; p66shc both promotes oxidative stress and suppresses the pro-survival ERK/CREB/HO-1 signaling pathway. PMID:28155123
5. p66Shc is a regulator of renal vascular tone and a driver of impaired renal vascular function in hypertension-induced nephropathy PMID:27270176
6. SIRT1 inhibition significantly abrogated the suppression of p66Shc expression. PMID:26845416
7. The results support a link between liver cell apoptosis and the miR-34a/SIRT1/p66shc pathway, which can be modulated by carnosic acid in nonalcoholic fatty liver disease. PMID:26203862
8. p53-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity PMID:25810038
9. that p52SHC3 plays an important role in maintaining the mitotic quiescence of neurons, while p52SHC1 regulates the proliferation of neural stem cells PMID:26058566
10. Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate. PMID:24085465
11. Data suggest that vascular activity of penile/cavernosal tissue is impaired by upregulation of p66Shc and Bip/Hspa5 (Ig heavy-chain binding protein/heat shock protein 5) in diabetic corpus cavernosum of penis leading to erectile dysfunction. PMID:23215692
12. p66-Shc gene expression is specifically up-regulated in the aged liver and brain. PMID:22130185
13. This is the first work to demonstrate the essential role of p66(shc) in mediating requisite mitochondrial and energetic compensation after preconditioning and suggests a mechanism by which protein and organelle damage mediated by ROS can increase HSP70. PMID:20392947
14. The Shc1 signal pathway if critical in angiotensin II-dependent smooth muscle vascular endothelial cell division. PMID:12837289
15. data show that the regulation of Shc mRNAs in senescence is region as well as isoform specific PMID:12882334
16. p66Shc isoform exerts an inhibitory effect on the mitogen-activated protein kinase signaling pathway in rodent myoblasts. PMID:15262993
17. conclude that the expression of p66Shc protein is regulated by signaling through the thyrotropin receptor in proliferating thyroid cells PMID:15705774
18. p66(shc) regulates mitochondrial oxidative capacity and may extend life span by repartitioning metabolic energy conversion away from oxidative and toward glycolytic pathways PMID:16481327
19. A functional role for Shc and likely FRS2 in ALK-dependant MAP-kinase activation and neuronal differentiation of PC12 cells. PMID:17274988
20. the increased phosphorylation of p66shc is one of the important mediators in the impaired endothelium-dependent relaxation of aortic coarctation rats. PMID:18588882
21. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. PMID:19060130
22. p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. PMID:19168439

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UNIGENE: Rn.138818

KEGG: rno:85385

STRING: 10116.ENSRNOP00000028038