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Recombinant Rat SH3 and multiple ankyrin repeat domains protein 2 (Shank2), partial

Recombinant Rat SH3 and multiple ankyrin repeat domains protein 2 (Shank2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Shank2

Purity

>85% (SDS-PAGE)

Target Names

Shank2

Uniprot NO.

Q9QX74

Alternative Names

AUTS17; Cortactin binding protein 1; Cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; KIAA1022; Proline rich synapse associated protein 1; Proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2_RAT; SHANK; Shank2; SPANK-3

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1474

Target Protein Sequence

MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAG APEWAVCSAA TSHRSLSPQL LQQTPSKPDG ATKSLGSYAP GPRSRSPSLN RLGGAGEDGK RPQPPHWHVG SPFTPGANKD SLSTFEYPGP RRKLYSAVPG RLFVAIKPYQ PQVDGEIPLH RGDRVKVLSI GEGGFWEGSA RGHIGWFPAE CVEEVQCKPR DSQAETRADR SKKLFRHYTV GSYDSFDAAS DCIIEDKTVV LQKKDNEGFG FVLRGAKADT PIEEFTPTPA FPALQYLESV DEGGVAWQAG LRTGDFLIEV NNENVVKVGH RQVVNMIRQG GNHLVLKVVT VTRNLDPDDT ARKKAPPPPK RAPTTALTLR SKSMTAELEE LGLSLVDKAS VRKKKDKPEE IVPASKPSRT AENVAIESRV ATIKQRPTSR CFPAASDVNS VYERQGIAVM TPTVPGSPKG PFLGLPRGTM RRQKSIDSRI FLSGITEEER QFLAPPMLKF TRSLSMPDTS EDIPPPPQSV PPSPPPPSPT TYNCPRSPTP RVYGTIKPAF NQNPVAKVPP ATRSDTVATM MREKGMFYRR ELDRFSLDSE DVYSRSPAPQ AAFRTKRGQM PENPYSEVGK IASKAVYVPA KPARRKGMLV KQSNVEDSPE KTCSIPIPTI IVKEPSTSSS GKSSQGSSME IDPQATEPGQ LRPDDSLTVS SPFAAAIAGA VRDREKRLEA RRNSPAFLST DLGDEDVGLG PPAPRMQPSK FPEEGGFGDE DETEQPLLPT PGAAPRELEN HFLGGGEAGA QGEAGGPLSS TSKAKGPESG PAAALKSSSP ASPENYVHPL TGRLLDPSSP LALALSARDR AMQESQQGHK GEAPKADLNK PLYIDTKMRP SVESGFPPVT RQNTRGPLRR QETENKYETD LSKDRRADDK KNMLINIVDT AQQKSAGLLM VHTVDIPVAG PPLEEEEDRE DGDTKPDHSP STVPEGVPKT EGALQISAAP EPAAAPGRTI VAAGSVEEAV ILPFRIPPPP LASVDLDEDF LFTEPLPPPL EFANSFDIPD DRAASVPALA DLVKQKKSDT PQPPSLNSSQ PANSTDSKKP AGISNCLPSS FLPPPESFDA VTDSGIEEVD SRSSSDHHLE TTSTISTVSS ISTLSSEGGE SMDTCTVYAD GQAFVVDKPP VPPKPKMKPI VHKSNALYQD TLPEEDTDGF VIPPPAPPPP PGSAQAGVAK VIQPRTSKLW GDVTEVKSPI LSGPKANVIS ELNSILQQMN RGKSVKPGEG LELPVGAKSA NLAPRSPEVM STVSGTRSTT VTFTVRPGTS QPITLQSRPP DYESRTSGPR RAPSPVVSPT ELSKEILPTP PSAAAASPSP TLSDVFSLPS QSPAGDLFGL NPAGRSRSPS PSILQQPISN KPFTTKPVHL WTKPDVADWL ESLNLGEHKE TFMDNEIDGS HLPNLQKEDL IDLGVTRVGH RMNIERALKQ LLDR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene References into Functions

Desipramine produced a significant increase of Shank2 mRNA levels 7 d after acute stress exposure. PMID:27890541
Shank2E is concentrated in the apical domain of renal PT cells, specifically binds NaP(i)-IIa via PDZ interactions, and undergoes P(i)-induced internalization. PMID:15917299
Shank2 is positioned to coordinate the regulated endocytic retrieval and downregulation of Sodium-Phosphate Cotransporter Proteins Type IIa in rat renal proximal tubule cells. PMID:20810910
Shank2 negatively regulates CFTR and this may play a significant role in maintaining epithelial homeostasis PMID:14679199
Liver epithelial cells express an ankyrin repeat-containing Shank2 isoform, termed Shank2E, that is poised to co-ordinate actin-dependent events at the apical membrane. PMID:14977424
Data show that ProSAP1 is present in the olfactory cilia. PMID:18596612

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Subcellular Location

Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine.

Protein Families

SHANK family

Tissue Specificity

Expressed in epithelial cells (at protein level). All isoforms except isoform 7 are expressed predominantly in brain, with highest levels in olfactory bulb, cerebral cortex, cerebellum, central gray matter and hippocampus. Moderate levels of expression ar

Database Links

UNIGENE: Rn.14545

KEGG: rno:171093

STRING: 10116.ENSRNOP00000067841

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