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Recombinant Rat Receptor-type tyrosine-protein phosphatase C (Ptprc), partial

Recombinant Rat Receptor-type tyrosine-protein phosphatase C (Ptprc), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ptprc

Uniprot NO.

P04157

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.

Gene References into Functions

The activity of SHP-1 was decreased after high partial pressure of oxygen treatment no matter what the duration was, while the activity of CD45 was decreased only after high partial pressure of oxygen that led to inhibition of lymphocyte function. PMID:21166153
CD22 binding to native CD45 PMID:12115612
the large CD45 ectodomain is required for optimal TCR signaling PMID:12496963
CD45 acts as a negative regulator of cytokine production. PMID:16263122