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Recombinant Rat Protein unc-13 homolog B (Unc13b), partial

Recombinant Rat Protein unc-13 homolog B (Unc13b), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Unc13b

Purity

>85% (SDS-PAGE)

Target Names

Unc13b

Uniprot NO.

Q62769

Alternative Names

Unc13b; Unc13h2Protein unc-13 homolog B; Munc13-2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1622

Target Protein Sequence

MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKNDEI CGTKNPTPHK ILLGTRFELP FDIPEEEARY WTYKLEQINA LADDNEYSSQ EESQRKLLPT AAAQCRHWTY LGWGEHQTFE DPDSAVDDRD SDYRSETSNS APPPYHTTTQ PNASAHQFPM PVPLPQQLFL QGSSRDSCND SMQSYDLDYP ERRALSPTSS SRYGSSCNVS RGSSLLSELD QYHEQDDDGR ERDSIHSSHS YGSLSRDGQA GLGEQEKALE VACESQKEKT GESKERDDAT VCPPSDLMLH KDLTLGPQES FPEEKASSPF TQARAHWFRA VTKVRLQLQE ISDDGDPSLP QWLPEGPAGG LYGIDSMPDL RRKKPLPLVS DLAMSLVQSR KAGITSAMAT RTSLKDEDLK SHVYKKTLQA LIYPISCTTP HNFEVWSATT PTYCYECEGL LWGLARQGMR CSECGVKCHE KCQDLLNADC LQRAAEKSSK HGAEDRTQNI IMAMKDRMKI RERNKPEIFE VIRDVFTVSK VAHVQQMKTV KQSVLDGTSK WSAKITITVV CAQGLQAKDK TGSSDPYVTV QVGKTKKRTK TIFGNLNPVW EEKFHFECHN SSDRIKVRVW DEDDDIKSRV KQRLKRESDD FLGQTIIEVR TLSGEMDVWY NLEKRTDKSA VSGAIRLQIN VEIKGEEKVA PYHVQYTCLH ENLFHYLTDI QGSGGVWIPD ARGDDAWKVY FDETAQEIVD EFAMRYGIES IYQAMTHFAC LSSKYMCPGV PAVMSTLLAN INAYYAHTTA STNVSASDRF AASNFGKERF VKLLDQLHNS LRIDLSTYRN NFPAGSPERL QDLKSTVDLL TSITFFRMKV QELQSPPRAS QVVKDCVKAC LNSTYEYIFN NCHDLYSHQY QLQEQPLEEP GPSIRNLDFW PKLITLIVSI IEEDKNSYTP VLNQFPQELN VGKVSAEVMW HLFAQDMKYA LEEHEKDRLC KSADYMNLHF KVKWLHNEYV RELPALQGQV PEYPAWFEQF VLQWLDENED VSLEFLRGGL ERDKRDGFQQ TSEHALFSCS VVDVFTQLNQ SFEIIRKLEC PDPSILAHYM RRFAKTIGKV LIQYADILSK NFPAYCTKER LPCILMNNMQ QLRVQLEKMF EAMGGKELDS EAADSLKELQ VKLNTVLDEL SMVFGNSFQV RIDECVRQMA DILGQVRGTG NASPNARASV AQDADSVLRP LMDFLDGNLT LFATVCEKTV LKRVLKELWR VVMNTMERVI VLPPLIDQTG TQLILTAAKE LSQLSKLKDH MVREETRNLT PKQCAVLDLA LDTVKQYFHA GGNGLKKTFL EKSPDLQSLR YALSLYTQTT DTLIKTFVRS QTAQVHDGKG IRFTANEDIR PEKGAGVDDP VGEVSIQVDL FTHPGTGEHK VTVKVVAAND LKWQTAGMFR PFVEVTMVGP HQSDKKRKFT TKSKSNSWTP KYNETFHFLL GNEEGPEAYE LQICVKDYCF AREDRVIGLA VMPLRDVAAK GSCACWCPLG RKIHMDETGM TILRILSQRS NDEVAREFVK LKSESRSIEE GS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release.

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.

Protein Families

Unc-13 family

Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain, predominantly in cerebral cortex, hippocampus and striatum.

Database Links

UNIGENE: Rn.10127

KEGG: rno:64830

STRING: 10116.ENSRNOP00000058802

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