Recombinant Rat Protein numb homolog (Numb)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Numb

Purity

>85% (SDS-PAGE)

Target Names

Numb

Uniprot NO.

Q2LC84

Alternative Names

Numb; Protein numb homolog

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-652

Target Protein Sequence

MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA TFDASRTTFT REGSFRVTTA TEQAEREEIM KQLQDAKKAE TDKTVGPSVA PGNSAPSPSS PTSPTLDPTA SLEMNNPHAI PRRHAPIEQL ARQGSFRGFP ALSQKMSPFK RQLSLRINEL PSTMQRKTDF PIKNTVPEVE GEAESISSLC SQITSAFSTP CEDPFSSAPM TKPVTLVAPQ SPVLQANGTD SALHVLTAKP ASTALAPVAM PVRETNPWAH APDAANKEIA AIHSGTEWGQ SSGAASPGLF QAGHRRTPSE ADRWLEEVSK SVRAQQPQAS AAPLQPVLQP PPPAAIAPPA PPFQGHAFLT SQPVPVGVVP PLQPAFVSTQ SYPVANGMPY PASNVPVVGI TPSQMVANVF GTAGHPQATH PHQSPSLAKQ QTFPQYETSS ATTSPFFKPS AQHLNGSAAF NGVDNSGLVS GNRPAQVPPG TCPVDPFEAQ WAALESKPKQ RTNPSPTNPF SSDAQKAFEI EL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Database Links

UNIGENE: Rn.102078

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