Recombinant Rat Protein jagged-1 (Jag1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Jag1

Purity

>85% (SDS-PAGE)

Target Names

Jag1

Uniprot NO.

Q63722

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis.

Gene References into Functions

Overexpression of Jagged1 ameliorates aged rat-derived endothelial progenitor cell functions and increases its transfusion efficiency for balloon-induced rat arterial injury. PMID:28163178
Jag1 can attenuate restenosis of vein graft by inducing decreased proliferation and increased apoptosis in vivo. PMID:25660475
Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID:24907271
This is the first study to demonstrate that Jagged1 delivery transiently activates Notch signaling and increases osteogenesis. PMID:23775982
an imbalanced interaction of Jagged1 expression in periductal and periportal myofibroblasts and Notch2 expressed in cholangiocytes, may be involved in the formation of bile duct lesions in Polycystic kidney rats PMID:23331119
Data indicated that Recombinant Rat Jagged 1 Fc Chimera promoted adipogenic differentiation of mouse adipose-derived stem cells. PMID:23046039
Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT PMID:16413496
Jagged1 may play a critical role in mediating the parathyroid hormone (PTH)-dependent expansion of hematopoietic stem cells, as well as the anabolic effect of PTH in bone PMID:16647886
Recombinant rat Jagged-1-mediated signaling induces a unique form of human T cell suppression whereby T cells proliferate normally upon secondary stimulation but secrete significantly reduced levels of cytokine. PMID:17475842
Jagged1 enhances the self-renewal of neural crest stem cells in vitro without affecting their sensitivity to instructive differentiation signals. PMID:17761753
Ageing enhanced vascular smooth muscle proliferation through impaired endothelial cell Jagged1 expression after vascular injury. PMID:18079106
mRNA expression of Notch-1 and its ligand Jagged-1 is upregulated in postnatal rat microglia of the corpus callosum and subventricular zone, but that of Delta-1 is reduced. PMID:18449946