Recombinant Rat Protein C-ets-1 (Ets1)

1. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor. PMID:29856744
2. data indicate a role for ETS-1 in the control of the GAL2R gene expression. PMID:27349435
3. Reduced renal expression of ETS-1 prevented hypertension-associated kidney injury in SS rats PMID:28696249
4. miR-125a-5p directly targets ETS-1, a transcription factor implicated in cell proliferation and migration and is crucial in PDGF-BB pathway in vascular smooth muscle cells. PMID:28502794
5. Knockdown of Ets-1 by siRNA significantly inhibited the inductive effects of Ang II on cell proliferation and expression of CTGF and PAI-1 PMID:26617730
6. Knockdown of miR-208b-3p expression attenuated apoptosis, while knockdown of Ets1 promoted apoptosis in myocardial ischemia reperfused rats. PMID:26658785
7. that salt-sensitive hypertension results in increased glomerular expression of phosphorylated ETS-1 and suggested that ETS-1 plays an important role in the pathogenesis of end-organ injury in salt-sensitive hypertension. PMID:25624342
8. ETS-1 overexpression induces beta-cell dysfunction partly through up-regulation of COX-2 gene expression. PMID:24287791
9. These data indicate that Ets-1 may influence neuronal injury following ischemia. PMID:23246490
10. Decreased expression of Ets-1 and increased expression of TIMP-2 may play an important role in the development of glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy PMID:20598359
11. Ets-1 plays a critical role in the regulation of endogenous prolactin gene expression and prolactin protein production. PMID:12668863
12. Ets-1 has a role in regulation of p21WAF1/Cip1 PMID:12740370
13. The colocalization of Ets-1 and HIF-1alpha in hypoxic areas suggests that hypoxia may induce Ets-1 and HIF-1alpha expression during joint inflammation PMID:14730627
14. PDGF-BB and Ets-1 may contribute to smooth muscle cell phenotypic switching associated with vascular injury. PMID:14751865
15. A temporal increase of mesangial cell Ets-1 expression correlates with mesangial cell activation in mesangioproliferative glomerulonephritis PMID:15253715
16. The Ets-1 pathway may regulate the transcription of cyclin D1 and control the regeneration of renal tubules in acute renal failure PMID:15579511
17. The Ets-1 transcriptional factor may participate in IL-1beta-mediated MMP-9 expression in tubulointerstitial cells. PMID:16046515
18. Sp1, like Ets-1, induces PDGF-D transcription and mRNA expression; H2O2 stimulates Ets-1, but not Sp1, and activates D3-dependent PDGF-D transcription PMID:16189269
19. Ets-1 promotes degradation of extracellular matrix proteins and is critical for integral kidney glomerular reorganization PMID:16738537
20. Ets family members Ets-1 and Elk-1 can positively regulate COX-2 promoter activity. PMID:17505916
21. VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy. PMID:17622743
22. Despite lacking an obvious motif for a canonical D-site sequence, recognized by ERK2 and used to promote catalysis, transcription factor Ets-1 is efficiently phosphorylated by ERK2 and is shown to interact with it. PMID:17658891
23. diabetes may contribute to increased cell proliferation due to N-ras constitutive activation, as well as to enhanced invasion and metastatic potential by increasing ets-1 levels PMID:17708355
24. Ets-1 may participate and play an important role in the regulation of follicular development, corpus luteum formation, maintenance, and regression in estrus and pregnancy in rats. PMID:18439600
25. Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells. PMID:18636553
26. Ets transcription factors play important roles for basic properties of rat C6 glioma cells, and targeting of these factors may become a useful tool for therapeutic strategies against malignant gliomas. PMID:19148472

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UNIGENE: Rn.88756

KEGG: rno:24356

STRING: 10116.ENSRNOP00000062912