Recombinant Rat Protein AATF (Aatf)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Aatf

Purity

>85% (SDS-PAGE)

Target Names

Aatf

Uniprot NO.

Q9QYW0

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-523

Target Protein Sequence

AELQPLALQ LEQLLNPRPR EADPEADPEE ATRARVIDRF DEGEEEEDDL PVSSIRKLAP VSLLDTDKRY SGKTTSRKAW KEDHWDQTLP SSSDNEIPDE GGSEAGDSEG LEELSEDVEE DLEDNEIPDE GGSEDGDSEG LEEEISEDVE EDLEGEDEED REEDRNSEDD GVVMAFSGVK VSEEVEKGRA VKNQIALWDQ LLEGRIKLQK ALLTTNQLPQ PDVFPVFKDK GGPEFASALK NSHKALKALL RSLVDLQEEL LFQYPDTRYL VKGTKPNAES EEISSEDDEL VGEKKKQRKA PPKRKLEMED YPSFMAKRSA DFTVYRNRTL QKWHDKTKLA SGKLGKGFGA FERSILTQID HILMDKERLL RRTQTKRSAY RVLGKPEPVP EPVAETLPGE PESLPQVPAN AHLKDLDEEI FDDDDFYHQL LRELIERKTS SLDPNDQVAM GRQWLAIQKL RSKIRKKVDR KASKGRKLRF HVLSKLLSFM APIDHTAMND EARTELYRSL FGQLNRLDAD HGQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.

Gene References into Functions

Che-1 plays an important role in neuronal apoptosis following traumatic brain injury. PMID:23007641
Ectopic expression of AATF or a constitutively active form of AKT1 confers on cells resistance to ER stress-mediated cell death, whereas RNAi-mediated knockdown of AATF or AKT1 renders cells sensitive to ER stress. PMID:19911006
apoptosis-antagonizing transcription factor binds to TSG101 in a process that enhances androgen receptor-mediated transcription by promoting its monoubiquitination PMID:14761944
In search of novel interaction partners of AATF, we identified BLOS2 (BLOC1S2, also termed Ceap) from a rat cDNA library. PMID:17552904