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Recombinant Rat Proliferating cell nuclear antigen (Pcna)

Recombinant Rat Proliferating cell nuclear antigen (Pcna)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pcna

Uniprot NO.

P04961

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-261

Target Protein Sequence

MFEARLIQGS ILKKVLEALK DLINEACWDI SSGGVNLQSM DSSHVSLVQL TLRSEGFDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVSIEMN EPVQLTFALR YLNFFTKATP LSPTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

Gene References into Functions

The damaged retinal pigment epithelium showed earlier expression of PCNA and RPE65 than photoreceptor out segments PMID:29569173
Taken together, these results indicated that ALA protected dopaminergic neurons against MPP+induced neurotoxicity through its ability to upregulate the DNA repair protein, PCNA, via the P53 pathway. PMID:27665784
This indicates that MPP+-induced oxidative damage is mediated by the downregulation of PCNA through the p53 pathway in a cellular model of Parkinson's disease . PMID:26677001
PCNA index decreased from 80 in HCC rats to 32 after boron treatment. PMID:23219601
The positive expression of PCNA in intestinal epithelial cells at the early development stage was much stronger and more extensive than that in mature rats. Expression was limited to intestinal crypts. PMID:12857463
Islet cell tumors were associated with increased nuclear expression of cyclin-dependent kinase 4 as well as increased proliferating cell nuclear antigen and decreased beta-catenin expression. PMID:22477723
Fluorine possibly damages the male reproductive system by reducing the expression of TERT and PCNA. PMID:17456401
Sex-associated difference in PCNA expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats. PMID:22330348
Glutamine supplementation rapidly improved the expression of PCNA after cisplatin-induced intestinal mucosal injury. PMID:21080177
Following melatonin treatment, pinealectomized female rats present signals of proliferation on ovarian surface epithelium and interstitial cells as well as high expressions of ovarian PCNA and vascular endothelial growth factor. PMID:20605140
High omega-6 polyunsaturated fatty acid diet can enhance azoxymethane-induced inhibition of P53 in colon mucosa, resulting in overexpression of PCNA, formation of aberrant crypt foci, and carcinogenesis in the colon. PMID:20972911
After treatment with Buyang Huanwu Decoction PCNA level was increased in rats with aortic intimal injuries. PMID:18664354
Compared with the control group, the PCNA level in the thyroid of rats given propylthiouracil for 3 days significantly increased. PMID:18390212
Exposure to diesel exhaust particles elevated transcription of proliferating cell nuclear antigen gene in rat alveolar macrophages. PMID:12011483
The presence of PCNA in a key anatomical location pertinent to an evolving ischaemic lesion indicates that PCNA influences cell survival in ischaemically compromised tissue. PMID:12099899
PCNA expression gradually decreased from prenatal day 19 onwards and has a role in growth regulation in the developing rat heart PMID:12389741
data show that changes in liver expression of DNA polymerase beta, Ref-1, proliferating cell nuclear antigen, and Bax are associated with peroxisome proliferator-induced carcinogenesis PMID:12565796
Activation of vascular smooth muscle cell Ca2+ channels and CaMKII is a key early signaling event required for upregulation of PCNA gene expression in VSMCs after oxidative injury to endothelium. PMID:12969989
ERK1/2 has a role in FSH induced PCNA expression and steroidogenesis in granulosa cells PMID:15569628
Examination by immunofluorescence techniques of tracheal cell cultures after exposure to very low doses of alpha particles revealed a large proportion of cells with proliferating cell nuclear antigen (PCNA) bound in their nuclei. PMID:15606305
PCNA-positive cell level was markedly higher in cadmium intoxication in submandibular gland. PMID:15638412
PCNA may play an important role in the damage and repair of intestinal mucosa in intrauterine ischemia PMID:15818741
regulation of PCNA through YY1 is affected by nucleophospmin/B23 PMID:16099430
In HCC, there was positive correlation between p-Stat3 level and the expression of TGFalpha and PCNA. PMID:17031671
PCNA may play a role in abnormal placenta formation resulting from diabetes PMID:18377963
Ovarian follicle counts using Pcna and semi-automated image analysis is reported. PMID:18467674
Pcna indexing as a preclinical immunohistochemical biological marker for testicular toxicity is reported. PMID:19016366
Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats. PMID:19032457