Recombinant Rat Pro-cathepsin H (Ctsh)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ctsh

Uniprot NO.

P00786

Alternative Names

CtshPro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H; EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

96-103

Target Protein Sequence

EPQNC SAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important for the overall degradation of proteins in lysosomes.

Gene References into Functions

cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways PMID:27998776
The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID:24982147
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID:21217776
involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes PMID:12034564