Recombinant Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Hcn4), partial

1. Data suggest that HCN channels might play an important role in affecting contraction frequency of lymphatic muscle cells. PMID:27496876
2. the expression and relative abundances of HCN channels in cerebellum and primary cultures of cerebellar granule neurons, is described. PMID:27569278
3. involved in microwave-induced heart pacemaker cell injuries PMID:26695361
4. Spironolactone increased miRNA-1 expression in myocardium after myocardial infarction. Upregulation of miRNA-1 expression contributed to the posttranscriptional repression of HCN2/4 expression. PMID:26065643
5. The results of this study indicated that HCN4 subunits are expressed in several populations of spinal and hippocampal interneurons. PMID:23357121
6. The data of this study indicated a HCN subunit shift initiated in the first 24 hours after birth and implicate a prominent perinatal role of the phylogenetically older HCN3 and/or HCN4 subunits in the developing neocortex. PMID:22694806
7. first report that Thy1 colocalizes and coimmunoprecipitates with a membrane-spanning protein in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subunit protein (HDN4) PMID:22281825
8. The moderate-intensity HCN4 band density in trigeminal ganglion neurons increased with postnatal age P1-P35. PMID:21753027
9. This study demonistrated that the majority of LHb neurons projecting to the monoaminergic brainstem nuclei express a similar pattern of HCN transcripts, with high levels of HCN2 to HCN4 mRNAs and low levels of HCN1 mRNA. PMID:21798320
10. Results describe HCN1 and HCN4 immunoreactivity in rat retinal ganglion cells, measure I(h) in dissociated cells, and show that HCN1 and HCN4 proteins colocalize in single retinal ganglion cells. PMID:21456027
11. HCN1 and HCN4 in postnatal afferent fibers and HCN1, HCN2, and HCN4 after hearing onset; HCN channels mediate hyperpolarization-activated current (I(h)); results suggest that I(h) is active at rest and shortens EPSPs, potentially improving signaling PMID:20220080
12. HCN4 was present in 9% of rat trigeminal ganglion neurons and 4.7% of dorsal root ganglion neurons PMID:19820968
13. densely clustered at synaptic terminals of retinal bipolar cells and photoreceptors PMID:12786975
14. Immunoreactivity for HCN4 in rat brain exhibits subcortical distribution mainly concentrated in the thalamus. PMID:14991560
15. We explored the functional role of the I(H) channels in sensory neurons isolated from rat nodose ganglia. Immunohistochemical studies demonstrated differential distribution of HCN1, HCN2, and HCN4 in sensory neurons and peripheral nerve terminals PMID:15056713
16. subcellular expression patterns of the HCN channel isoforms support age-specific properties and functions of I(h) within the developing hippocampal formation PMID:16648453
17. Our data extend our previous discovery of Ca(2+) influx in I(h) channels in neurons to I(f) channels in cardiac myocytes. PMID:17065201
18. We conclude that the NRSE-NRSF system was implicated in HCN4 expression in cardiac myocytes. PMID:17173866
19. findings confirm presence of HCN-1, -2, and -4 in cone bipolar cells and provide evidence that the type 5 cone bipolar cell includes two distinct cell types, only one of which expresses HCN channels PMID:17311321
20. HCN2-HCN4 heteromeric channels form in native tissue to make functional pacemaker channels PMID:17553794
21. Adult VCM in primary culture undergo changes in I(f) expression reminiscent of in vivo hypertrophy; endothelin-1 (but no angiotensin-II) seems to play a role in ionic remodeling. PMID:18255311
22. HCN4-like immunoreactivity in rat retinal ganglion cells. PMID:18282314
23. Recycling endosomes serve as an intracellular storage compartment for the cardiac pacemaker channels HCN2 and HCN4. PMID:18326556
24. In adult myocytes overexpressing HCN4, there was an associated increase in HCN2 mRNA. In neonatal myocytes in which HCN2 was knocked down, there was also a simultaneous decrease in HCN4 mRNA. PMID:19236845
25. overexpression of a dominant negative MEF2 mutant inhibited the enhancer activity of CNS13, decreased Hcn4 mRNA expression and also decreased the amplitude of I(h) current in myocytes isolated from the inflow tract of embryonic heart PMID:19477969

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UNIGENE: Rn.41082

KEGG: rno:59266

STRING: 10116.ENSRNOP00000012644