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Recombinant Rat Platelet-derived growth factor D (Pdgfd)

Recombinant Rat Platelet-derived growth factor D (Pdgfd)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Pdgfd

Purity

>85% (SDS-PAGE)

Target Names

Pdgfd

Uniprot NO.

Q9EQT1

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

24-370

Target Protein Sequence

TPQSASI KALRNANLRR DESNHLTDLY RRDENIRVTG TGHVQSPRFP NSYPRNLLLT WRLHSQEKTR IQLAFDHQFG LEEAENDICR YDFVEVEDVS ESSTVVRGRW CGHKEIPPRI TSRTNQIKIT FQSDDYFVAK PGFKIYYSFV EDFQPEAASE INWESVTSSF SGVSYHSPSV MDSTLTADAL DKAIAEFDTV EDLLKYFNPA SWQDDLENLY MDTPRYRGRS YHERKSKVDL DRLNDDVKRY SCTPRNHSVN LREELKLTNA VFFPRCLLVQ RCGGNCGCGT LNWKSCTCSS GKTVKKYHEV LKFEPGHFKR RGKAKNMALV DIQLDHHERC DCICSSRPPR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. May play an important role in control of lens epithelial cell proliferation. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.

Gene References into Functions

Podocyte-specific PDGF-D overexpression caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis. Podocyte-specific PDGF-D overexpression induced paracrine mesangial cell proliferation upstream of the filtration flow. PMID:21866094
The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system PMID:11850188
PDGFD is expressed in the eye and has a key role in control of lens epithelial cell proliferation PMID:15611105
These results support the fact that PDGF-D is involved in the formation of neointimal hyperplasia induced by balloon catheter injury and may serve as a target in preventing vascular restenosis after coronary angioplasty. PMID:15752751
PDGF-D possesses potential pathogenetic properties for HSC activation and matrix remodeling in liver fibrosis PMID:17397961
All 3 residues in Sp1 (Thr668, Ser670, and Thr681) are required for Sp1-dependent platelet-derived growth factor-D activation in response to angiotensin II PMID:18258854
alloimmune response induces PDGF-A, PDGF-C, and PDGF-D expression in the graft vasculature;PDGF-D mediated profibrotic and proarteriosclerotic effects in transplanted hearts involving the TGF-[beta]1 pathway PMID:19213942

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Subcellular Location

Secreted.

Protein Families

PDGF/VEGF growth factor family

Tissue Specificity

Widely expressed. Expressed at high levels in the kidney, adrenal glands, eye and CNS. In the kidney the localization is confined to arterial and arteriolar vascular smooth muscle cells and is also detected at low levels in the glomeruli In the eye in the

Database Links

UNIGENE: Rn.64493

KEGG: rno:66018

STRING: 10116.ENSRNOP00000039308

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