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Recombinant Rat Platelet-derived growth factor C (Pdgfc)

Recombinant Rat Platelet-derived growth factor C (Pdgfc)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Pdgfc

Purity

>85% (SDS-PAGE)

Target Names

Pdgfc

Uniprot NO.

Q9EQX6

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

23-345

Target Protein Sequence

ESNLSSKL QLSSDKEQNG VQDPRHERVV TISGNGSIHS PKFPHTYPRN TVLVWRLVAV DENVRIQLTF DERFGLEDPE DDLCKYDFVE VEEPSDGSVL GRWCGSGTVP GKQTSKGNHI RIRFVSDEYF PSEPGFCIHY SIIMPQVTET TSPSVLPPSA LSLDLLNNAV TAFSTVEELI RFLEPDRWQI DLDSLYKPTW PLLGKAFLYG KKSKAVNLNL LKEEVKLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPRK VTKKYHEVLQ LRPKIGVKGL HKSLTDVALE HHEECDCVCR GNTEG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.

Gene References into Functions

After experimental liver fibrosis, induced by bile-duct occlusion, miR-29 expression was shown to be reduced, but IGF-I and PDGF-C expression was upregulated, correlating inversely to the miR-29 pattern. PMID:22565577
The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. PMID:11850188
PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK PMID:15247255
ATII induction of PDGF-C transcription is mediated by the angiotensin type 1 receptor and through an Egr-1-binding element in the PDGF-C promoter. PMID:18272536
might be involved in the pathogenesis of periapical lesions PMID:19249599

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Subcellular Location

Cytoplasm, cytosol. Secreted. Nucleus. Cytoplasmic granule. Cell membrane.

Protein Families

PDGF/VEGF growth factor family

Tissue Specificity

Highly expressed in the kidney and adrenal gland. In the kidney, it is expressed in arteriolar smooth muscle cells and in epithelial cells of individual segments (at protein level).

Database Links

UNIGENE: Rn.211987

KEGG: rno:79429

STRING: 10116.ENSRNOP00000015081

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