Recombinant Rat Phospholipase D2 (Pld2), partial

1. Phosphatidic acid produced by PLD2 plays an important role in regulating cell morphology in mast cells. PMID:22344748
2. A high level of cell invasiveness of cancer cells can be explained for the first time by combined high JAK3/PLD2 phosphorylation and activity involving PLD2's Y415 residue, which might constitute a novel target to inhibit cancer cell invasion. PMID:21414324
3. Data demonstrate that alpha-syn is an inhibitor of PLD2 in vivo. PMID:20664530
4. Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARgamma by cyclic phosphatidic acid. PMID:20705243
5. The level of PLD2 in both the cerebrum and hindbrain was minimal compared to that of PLD1. PMID:19010519
6. ARF6 protein regulates mu-opioid receptor trafficking and signaling via PLD2 activation and hence affects the development of opioid receptor desensitization and tolerance. PMID:19666113
7. PKC delta-dependent direct phosphorylation plays an important role in the regulation of PLD2 activity in PC12 cells. PMID:11744693
8. interaction with aldolase via PH domain PMID:11876650
9. stimulates cell protrusion in V-Src transformed cells PMID:12054584
10. gene expression and stablity in primary astrocytes PMID:12270129
11. Data show that phospholipases D1 and D2 (PLD1 and PLD2) are expressed in mast cells and that PLD2 localizes to membrane ruffles of antigen-stimulated mast cells together with endogenous ADP ribosylation factor 6 (ARF6). PMID:12388770
12. demonstrate a significant fraction of endogenous PLD2 localized to the perinuclear Golgi region and was also distributed throughout cells in dense cytoplasmic puncta; data are consistent with a model whereby PLD2 plays a role in Golgi vesicular transport PMID:12429836
13. PC12 cells require PLD2 to attentuate glutamate-induced cell death. PMID:12642902
14. PLD2 has a role in activation of phospholipase C gamma 1 and is important for its activity PMID:12646582
15. H2O2 modifies GAPDH on its catalytic cysteine residue not only to inactivate the dehydrogenase activity of GAPDH but also to endow GAPDH with the ability to bind PLD2 and the resulting association is involved in the regulation of PLD2 activity by H2O2 PMID:12753082
16. direct evidence for linkages between PLD2, ROS production, and S100B-RAGE-induced enhancement of Ang II-induced cell proliferation and activation of JAK2 in VSMCs. PMID:12941779
17. PLD2 functions at the plasma membrane to facilitate endocytosis of the angiotensin II type 1 receptor. PMID:14718562
18. PLD2 expression in choroid plexus and ventricular zone of lateral and third ventricles at embryonic day 15 and also in developing cerebral cortex and hippocampus suggests PLD2 involvement in early developmental processes of some neuronal progenitors. PMID:15036596
19. Interaction with dynamin may be involved in enzyme activation. PMID:15581494
20. These data suggest that the ANG II-induced neointimal growth is mediated by the activation of Akt through a mechanism dependent on cPLA2 and PLD2 activation in balloon-injured rat carotid arteries. PMID:16024570
21. Antigen stimulation resulted in increased association and colocalization of Syk with PLD2 on the plasma membrane, an early critical event in the activation of mast cells. PMID:16861349
22. First demonstration that PLD2 activation is involved in GAP-43 and synapsin I expression during depolarization-induced neuronal differentiation in PC12 cells. PMID:18004999

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UNIGENE: Rn.9798

KEGG: rno:25097