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Recombinant Rat Peripheral plasma membrane protein CASK (Cask), partial

Recombinant Rat Peripheral plasma membrane protein CASK (Cask), partial

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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Cask

Purity

>85% (SDS-PAGE)

Target Names

Cask

Uniprot NO.

Q62915

Alternative Names

Cask; Peripheral plasma membrane protein CASK; EC 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-909

Target Protein Sequence

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHHVVAHE VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS VSIYVRAQFE YDPAKDDLIP CKEAGIRFRV GDIIQIISKD DHNWWQGKLE NSKNGTAGLI PSPELQEWRV ACIAMEKTKQ EQQASCTWFG KKKKQYKDKY LAKHNADLVT YEEVVKLPAF KRKTLVLLGA HGVGRRHIKN TLITKHPERF AYPIPHTTRP PKKDEENGKN YYFVSHDQMM QDISNNEYLE YGSHEDAMYG TKLETIRKIH EQGLIAILDV EPQALKVLRT AEFPPFVVFI AAPTITPGLN EDESLQRLQK ESDVLQRTYA HYFDLTIINN EIDETIRHLE EAVELVCTAP QWVPVSWVY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.

Gene References into Functions

induction of beta cell insulin-secretion defects by fatty acids is mediated, at least in part, by FOXO1 via downregulation of Cask expression PMID:25796372
The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane. PMID:23542924
Our study suggests that the stimulation of beta-cell insulin secretion by Ex-4 is mediated, at least in part, by CASK via a novel signaling mechanism. PMID:24140090
Depletion of liprin-alpha2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-alpha2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic vesicle release. PMID:23751498
Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation. PMID:19781660
analysis of the nucleotide binding domain of CASK PMID:12482754
interacts with CIP98; co-localizes with CIP98 along the dendritic processes of neurons PMID:12641734
CASK and Dlg may act as a scaffold for organizing receptors and channels at the postsynaptic membrane of the neuromuscular junction. PMID:15266631
In conclusion, our study suggests that the CASK protein complex not only functions as a scaffold but also recruits signaling molecules and may contribute to signal transduction. PMID:17084383
Data show that Cask is present in the olfactory cilia. PMID:18596612
The function of calcium/calmodulin-dependent serine protein kinase (CASK), a MAGUK protein, in dendritic spine formation by RNA interference, is analyzed. PMID:18606847
The Tbr-1-CASK-CINAP complex regulates expression of NR2b;a Thr-to-Ala point mutation in CASK affects NR2b promoter activity. PMID:19275891