Recombinant Rat Paxillin (Pxn)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Pxn

Purity

>85% (SDS-PAGE)

Target Names

Pxn

Uniprot NO.

Q66H76

Alternative Names

Pxn; Paxillin

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-586

Target Protein Sequence

MDDLDALLAD LESTTSHISK RPVFLSEEPP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG TVLDPLDQWQ PSGSRYAHQQ PPSPSPIYSS STKNSSASNP QDSVGSLCSR AGEEEHVYSF PNKQKSAEPS PTVMSSSLGS NLSELDRLLL ELNAVQRSPS GFSAGMVSVQ ASREPLGSWG TEGRAIILSP FFQDEAESSP PLPGALSPLY GVPESNNLLG GKAGPLMKEK PKRNGGRGLE DVRPSVESLL DELENSVPSP VPAITVNQGE MSSPQRVTSS QQQTRISASS ATRELDELMA SLSDFKFMAQ GKTGSSSPPG GLSKPGSQLD SMLGSLQSDL NKLGVATVAK GVCGACKKPI AGQVVTAMGK TWHPEHFVCT HCQEEIGSRN FFERDGQPYC EKDYHSLFSP RCYYCNGPIL DKVVTALDRT WHPEHFFCAQ CGAFFGPEGF HEKDGKAYCR KDYFDMFAPK CGGCARAILE NYISALNTLW HPECFVCREC FTPFVNGSFF EHDGQPYCEV HYHERRGSLC SGCQKPITGR CITAMAKKFH PEHFVCAFCL KQLNKGTFKE QNDKPYCQSC FLKLFC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

Gene References into Functions

downregulation of paxillin results in inhibition of dysregulation of cytoskeletal proteins and proliferation of pulmonary artery smooth muscle cells, suggesting a potential therapeutic effect on pulmonary vascular remodelling in Hepatopulmonary syndrome PMID:24457422
The dynamic expression of paxillin in rat pancreas from different stages indicates that paxillin might be involved in some aspects of pancreatic development. PMID:22110278
In mesenteric arteries an intact cytoskeleton and force development are necessary for the translocation of PYK2 and paxillin to the membrane PMID:15911746
Paxillin-S273 phosphorylation dramatically increases migration, protrusion, and adhesion turnover by increasing paxillin-GIT1 binding and promoting the localization of a GIT1-PIX-PAK signaling module near the leading edge. PMID:16717130
Paxillin associated with clustered IgE-Fc epsilonRI has a net positive effect on Fc epsilonRI signaling. PMID:19004813
Data show that CXCL8 stimulation leads to paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors (CXCR1 and CXCR2) mediate CXCL8-induced paxillin phosphorylation. PMID:19151925