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Recombinant Rat Parathyroid hormone-related protein (Pthlh)

Recombinant Rat Parathyroid hormone-related protein (Pthlh)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pthlh

Uniprot NO.

P13085

Alternative Names

Pthlh; Pthrp; Parathyroid hormone-related protein; PTH-rP; PTHrP; Parathyroid hormone-like protein; PLP) [Cleaved into: Osteostatin]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

37-177

Target Protein Sequence

AVSE HQLLHDKGKS IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRREQEKKK RRTRSAWPGT TGSGLLEDPQ PHTSPTSTSL EPSSRTH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.; Osteostatin is a potent inhibitor of osteoclastic bone resorption.

Gene References into Functions

These results indicate that the well-conserved region in the signal peptide plays an essential role in the dual localization of PTHrP through ER targeting and/or the membrane translocation. PMID:26538570
Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity. PMID:25278090
Goto-Kakizaki diabetic rats manifested a premature increase in chondrocyte apoptosis in the growth plate, and a compensatory overexpression of chondroregulatory proteins, such as PTHrP, Runx2, and VEGF. PMID:25159845
Pthlh is a promising candidate modifier gene in the development and progression of rat tongue cancers. PMID:24253735
The activation of Wnt or BMP4 pathways in rat XEN cells leads to the acquisition of VE characteristics, whereas the activation of the PTHRP/cAMP pathway leads to EMT and the formation of PE. PMID:23038778
Data indicate that PTH1R and PTHrP were more predominantly expressed in smooth muscle than in urothelium. PMID:23546599
Nicotine induces PTHrP expression in endothelial cells but excessive concentrations of nicotine reduce PTHrP receptor expression thereby attenuating any protective effects of PTHrP against apoptosis. PMID:22508055
PTHrP signaling can stimulate Notch signaling to promote the proliferation of epiphysis stem cells. PMID:22093939
The effects of lipopolysaccharide (LPS) on parathyroid hormone-related protein (PTHrP)-driven epithelial-mesenchymal interactions that are essential for normal lung development and homeostasis. PMID:17435078
The PTHrP and Ihh gene expressions decreased by 75 and 81%, respectively, although their protein expressions increased in surgically induced osteoarthritis. PMID:21073445
The down-regulation of Parathyroid hormone-related peptide favours atherosclerosis in chronic pressure overload. PMID:19910689
Parathyroid hormone-related protein induction in focal stroke: a neuroprotective vascular peptide. PMID:12456385
localization, expression and binding properties in enterocytes from 3 and 24 month old rats PMID:12647298
PTHrP may be involved in primary callus formation presumably co-operating with IGF-I in osteoblasts and osteocytes, and by regulating chondrocyte differentiation in endochondral ossification. PMID:12706025
in conditions in which stretch is increased, such as in hypertension or in restenosis after angioplasty, PTHrP may contribute to vessel hyperplasia. PMID:15579504
PTHrP is a candidate mediator of the anabolic effects of mechanical force on bone. PMID:16007342
parathyroid hormone-related peptide, by interaction with the PTH1 receptor, can increase tubulointerstitial cell survival and seems to act as a proinflammatory and profibrogenic factor in the FA-damaged kidney PMID:16672315
This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway. PMID:16940239
PTHrP induces HHM and concurrent cachectic syndromes by mechanisms other than directly modulating the leptin or hypothalamic feeding-regulated peptides PMID:17200368
On d 20 of gestation, RT-PCR analysis of uterine arteries showed that PTH/PTHrP receptor (PTH1R) mRNA expression was decreased, whereas that of PTHrP mRNA was increased PMID:18048500
Decreased food intake did not affect the expression of EGF, PTHLH, or LEP mRNA in mammary tissue. PMID:18401831
The regulation of PTH1R expression by endogenous PTHrP and the associated effects on vascular smooth muscle cell proliferation, was investigated. PMID:19574446