Recombinant Rat Paired box protein Pax-8 (Pax8)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pax8

Uniprot NO.

P51974

Alternative Names

Pax8; Pax-8; Paired box protein Pax-8

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-457

Target Protein Sequence

MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGSDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFG QHHLEPLECP FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS TLDDGKATLT PSNTPLGRNL STHQTYPVVA DPHSPYAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFSHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYASY SEAWRFPNSS LLSSPYYYSS TTRPSAPPTS ATAFDHL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

Gene References into Functions

Pax8 controls apical-basal follicular polarization and follicle formation through Cdh16. PMID:27780871
The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells. PMID:25270402
Pax8 is required for the survival of differentiated epithelial cells and its expression levels are able to modulate the proliferation rate of such cells. PMID:23868062
Distal regulation by Pax8 is supported by the interaction with chromatin remodeling factors such as CTCF and Sp1. PMID:22531031
Transcriptome analysis highlighted that Pax8 is a key molecule for thyroid morphogenesis and differentiation PMID:21966443
These results demonstrated that oxidoreductive modification of Cys-45 and Cys-57 via Ref-1 plays a role in redox regulation of Pax-8 in living cells. PMID:12237116
glutathionylation of the first two cysteines has a regulatory role in paired domain binding PMID:15888455
An unusual negative cross talk between Ras oncogene and the cyclic AMP pathway induces inactivation of the transcription factor Pax8. PMID:19282367