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Recombinant Rat Nuclear receptor corepressor 1 (Ncor1)

Recombinant Rat Nuclear receptor corepressor 1 (Ncor1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Ncor1

Purity

>85% (SDS-PAGE)

Target Names

Ncor1

Uniprot NO.

Q9WUB5

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-533

Target Protein Sequence

KDKGPPPKSR YEEELRTRGK TTITAANFID VIITRQIASD KDARERGSQS SDSSSSLSSH RYEAPSDAIE VISPASSPAP PQEKPQTYQP EMVKANQAEN ESPQQYEGPL THYRSQQGSP SPQQQPPLPP SSQAEGMGQV PRTHRLITLA DHICQIITQD FARNQVPSQP STSTFQTSPS ALSSTPVRTK PSSRYSPESQ SQTVLHPRPG PRVSPENLVD KSRGSRPGKS PERSHIPSEP YEPISPPQGP AVHEKQDSML LLSQRGMDPA EQRSDSRSPG SISYLPYFFT KLESTSPMVK SKKQEIFRKL NSSGGGDSDM AAAQPGTEIF NLPAVTTSGA VSSRSHSFAD PASNLGLEDI IRKALMGSFD DKVEDHGVVM PHPVGVVPGS ASTSVVTSSE TRRDEGDPSP HSGVCKPKLI NKSNSRKSKS PIPGQNYLGT ERPSSVSSVH SEGDYHRQTP GWAWEDRPSS TGSTQFPYNP LTIRMLSSTP PTPIACAPSA ITQAAPHQQS RIWEREPAPL LSAQYETLSD SDD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver.

Subcellular Location

Nucleus.

Protein Families

N-CoR nuclear receptor corepressors family

Database Links

UNIGENE: Rn.24948

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