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Recombinant Rat Neutrophil cytosol factor 2 (Ncf2)

Recombinant Rat Neutrophil cytosol factor 2 (Ncf2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ncf2

Uniprot NO.

A7E3N2

Alternative Names

Ncf2; Neutrophil cytosol factor 2; NCF-2; Neutrophil NADPH oxidase factor 2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-527

Target Protein Sequence

MSLAEAIRLW NEGVQAADKK DWKGALEAFS EVQDPHSRIC FNIGCMYTIL DNLQEAEQAF TKSINRDKHL AVAYFQRGML YYSMEKYRPA SVGRKAALLF LGSYNLVARI IVGYPLSPGK VLYNIALMHA KKEEWKKAEE QLALATNMKS EPRHSKIDKA MESIWKRCPT SHLPLDPPQV TMALWFEEGG VGKRSVVASV VHQDNFSGFA PLQPQSAEPP PRPKTPEIFR ALEGEAHRVL FGFVPETPEE LQVMPGNIVF VLKKGSDNWA TVMFNGQKGL VPCNYLEPVE LRIHPQSQPQ EDTSLESDIP PPPNSSPPER LQLSPGWCQQ LGPLRCPPFL LHQEVKRSVP MPYMLKVHYK YTVVMETQLG LPYSQLRNMV SKKLELLPEH TKLSYQRRDS PELLLLSEES MKDAWAQVKN YCLTLWCEHT VGDQGFVDEP KEKENSDADN RTTEPQPKEG TQVVAIFSYD ATQPEDLEFV EGDVILVLSH VNEEWLEGEC KGKIGIFPKA FVEGCAAKNL EGTPREV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Gene References into Functions

p67(phox) subunit of NADPH oxidase 2 plays an important role in the excess production of ROS from mitochondria in the renal medulla of the Dahl salt-sensitive rat. PMID:26062875
when the p67(phox)subunit of nicotinamide adenine dinucleotide phosphate-oxidase is not functional in the salt-sensitive rats, high salt diet does not cause reduced renal medullary blood flow and salt-sensitive hypertension is attenuated PMID:25489057
The expression of NCF2 was upregulated after IL-4 treatment for 4 h, but it was downregulated after 8-24 h. It was suppressesd by amyloid beta or dbcAMP. PMID:22565378
Candesartan may protect neurons by decreasing extracellular glutamate immediately after reperfusion and by attenuating oxidative stress via a modulation of the AT1-R signaling that occurs during ischemic insult. PMID:22661470