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Recombinant Rat Neurogenic locus notch homolog protein 3 (Notch3), partial

Recombinant Rat Neurogenic locus notch homolog protein 3 (Notch3), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

Notch3

Purity

>85% (SDS-PAGE)

Target Names

Notch3

Uniprot NO.

Q9R172

Alternative Names

Notch3; Neurogenic locus notch homolog protein 3; Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression.

Gene References into Functions

mild hypothermia inhibits Notch 3 and Notch 4 activation and seizure after stroke in the rat model PMID:29754932
Cysteine-sparing NOTCH3 missense mutations are associated with typical clinical CADASIL syndrome and typical magnetic resonance imaging (MRI) findings, although with less involvement of the anterior temporal lobe. PMID:28902129
We find that across species, the atypical receptor NOTCH3 is differentially overexpressed; it is progressively up-regulated with disease development and promotes tumor cell survival via activation of PI3k-Akt PMID:27791012
Notch3 signaling activation stimulated pulmonary vascular cells proliferation. PMID:26317171
Notch3, Jagged1, Hes1 and alpha-SMA were downregulated. This downregulation was accompanied by improved hepatic fibrosis after the inhibition of Notch3 in vivo. PMID:23918872
Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. PMID:22806125
These findings imply that Notch3 may not only be a regulator of fetal liver stem/progenitor cells differentiation into hepatocytes, but also be a potential marker of fetal liver stem/progenitor cells. PMID:22680933
Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation PMID:11925448
These results demonstrate that the Notch3 pathway is attenuated through IL-1beta and through NF-kappaB activation, allowing vascular smooth muscle cells to switch into an inflammatory state. PMID:17881497
Data demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. PMID:19640841

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Protein Families

NOTCH family

Tissue Specificity

Expressed in postnatal central nervous system (CNS) germinal zones and, in early postnatal life, within numerous cells throughout the CNS. It is more highly localized to ventricular germinal zones.

Database Links

UNIGENE: Rn.228683

KEGG: rno:56761

STRING: 10116.ENSRNOP00000037570

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