Recombinant Rat Myosin-7 (Myh7), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Myh7

Uniprot NO.

P02564

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1935

Target Protein Sequence

MADREMAAFG AGAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK IVSREGGKVT AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA SWMIYTYSGL FCVTVNPYKW LPVYNAQVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM LLITNNPYDY AFFSQGETTV ASIDDSEEHM ATDSAFDVLG FTPEEKNSIY KLTGAIMHFG NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC HPRVKVGNEY VTKGQNVQQV AYAIGALAKS VYEKMFNWMV TRINATLETK QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA KLYDNHLGKS NNFQKPRNIK GKQEAHFSLI HYAGTVDYNI LGWLQKNKDP LNETVVGLYQ KSSLKLLSNL FANYAGADAP VDKGKGKAKK GSSFQTVSAL HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLGSLD IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLSRME FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL KSAETEKEMA NMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ EAHQQALDDL QAEEDKVNTL TKAKVKLEQQ VDDLEGSLDQ DKKVRMDLER AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR TLEDQMNEHR SKAEETQRSV NDLTRQRAKL QTENGELSRQ LDEKEALISQ LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQDA EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD KILVEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS LEHEEGKILR AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRVVDSLQTS LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE VEEAVQECRN AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKNNMEQTI KDLQHRLDEA EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ HELDEAEERA DIAESQVNKL RAKSRDIGAK GLNEE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.

Gene References into Functions

results suggest that the betae3 site functions as a putative functional overload responsive element in the rat beta-MHC gene promoter PMID:11832337
higher levels of MHC-beta and dephosphorylated phospholamban may contribute to more contractile dysfunction in male than in female diabetic rat hearts PMID:12933346
findings suggest that the increased relative expression of MHC-beta is a compensation to sustain cardiac contractile efficiency in response to impaired oxidative metabolism in the hypoxia-induced hypertrophied ventricles PMID:12941647
cross-bridge cycling, under high strain, for alpha-MHC is three times higher than for beta-MHC. PMID:15471982
T3 treatment in hypothyroid animals caused beta-MHC mRNA to decline more rapidly than beta-MHC hnRNA, demonstrating, for the first time, a posttranscriptional mechanism(s). PMID:15650152
Bmyo cardiac myocytes were more responsive to changes in sarcomere length and lattice spacing. PMID:17347271
Beta-myosin heavy chain is a negative inotrope among the cardiac myofilament proteins. PMID:17363698
Exercise during chemical gonadectomy provided protection against hypogonadism-induced cardiac dysfunction by preserving myosin heavy chain distribution. PMID:17906105
Among 19 selected miRNAs, miR-27a was found to most strongly upregulate the beta-myosin heavy chain gene. PMID:21149577
visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO-MyHC developmental transitions PMID:21372011
Myocardial stiffness in a rat model of diabetes is studied. Short-range force, a cross-bridge based property, is increased in diabetic hearts. An increase in beta myosin heavy chain isoform expression is the likely mechanism. PMID:24012810
Cardiomyopathy mutations in the tail of beta-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes. PMID:24047955
results indicate that T3-bound TRs interfere with transactivation by TEADs via protein-protein interactions, resulting in the negative regulation of MYH7 promoter activity PMID:24781449
Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats PMID:12529291
Data show that reactive oxygen species mediate endothelin-1-induced activation of mitogen-activated protein kinase pathways, which culminates in hypertrophic responses and beta-myosin heavy chain expression. PMID:15864745