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Recombinant Rat Myocyte-specific enhancer factor 2D (Mef2d)

Recombinant Rat Myocyte-specific enhancer factor 2D (Mef2d)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mef2d

Uniprot NO.

O89038

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-507

Target Protein Sequence

MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSSVPAPNF AMPVTVPVSN QSSMQFSNPS SSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA SAGAMLGRDL NSANGACPNP VGNGYVSARA SPGLLPVANG NGLNKVIPAK SPPPPTHNTQ LGAPSRKPDL RVITSQGGKG LMHHLNNAQR LGVSQSTHSL TTPVVSVATP SLLSQGLPFS SMPTAYNTDY QLPSAELSSL PAFSSPAGLA LGNVTAWQQP QQPQQPQPPQ PPQSQPQPPQ PQPQQPPQQQ PHLVPVSLSN LIPGSPLPHV GAALTVTTHP HISIKSEPVS PSRERSPAPP PPAVFPAARP EPGEGLSSPA GGSYETGDRD DGRGDFGPTL GLLRPAPEPE AEGSAVKRMR LDTWTLK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.

Gene References into Functions

Study suggests that SU4312 provides therapeutic benefits in cellular and animal models of Parkinson's disease, possibly through multiple mechanisms including enhancement of myocyte enhancer factor 2D through the activation of PI3-K/Akt pathway. PMID:28807675
MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas MEF2C, despite its major role in cardiac morphogenesis and direct reprogramming, was dispensable for this process. PMID:28473466
MEF2D has a critical role in cell cycle regulation of post-mitotic, neonatal cardiomyocytes in vitro PMID:26294766
dysregulation of MEF2D by calpain may mediate excitotoxicity via an extrasynaptic NMDAR-dependent manner PMID:22215669
Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. PMID:20816781
These results suggest that PC12 cell death by 6-OHDA appears to be regulated by the down-regulation of MEF2D via some interaction between cdk5 and MAP kinase. PMID:21057871
Atorvastatin reverses hypertension-induced cardiac remodeling partially through down-regulation of PKD/MEF2D activation. PMID:19683055
TEF-1 and MEF2 (Mef2d) transcription factors interact to regulate cardiac myocyte-specific promoters. PMID:12061776
a novel role of MEF2 as a key nuclear mediator that may participate in the pathologic process of liver fibrogenesis in vivo. PMID:15480995
MEF2 is a target of cAMP-PKA pathway and PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival PMID:15735306
These results suggest that JMJ represses alphaMHC expression via protein-protein interaction with MEF2A. PMID:15737621
Muscle contraction leads to a rapid increase of MEF2D mRNA. PMID:16024167
results show that MEF2 transcription factors negatively regulate excitatory synapse number in an activity-dependent manner during synaptic development in vitro PMID:16484497
cAMP interferes with MEF2D-mediated gene expression at multiple levels by antagonizing the derepression of MEF2D by HDAC5 and by inhibiting recruitment of the co-activator NFAT. PMID:16870618
MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length. PMID:17945419
MEF2D is a novel downstream effector targeted by GSK3beta PMID:19801631