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Recombinant Rat Mothers against decapentaplegic homolog 9 (Smad9)

Recombinant Rat Mothers against decapentaplegic homolog 9 (Smad9)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Smad9

Uniprot NO.

O54835

Alternative Names

Smad9; Madh8; Madh9; Smad8; Mothers against decapentaplegic homolog 9; MAD homolog 9; Mothers against DPP homolog 9; SMAD family member 9; SMAD 9; Smad9; Smad8

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-434

Target Protein Sequence

MHPSTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMDELERALS CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPL ECCEFPFGSK QKEVCINPYH YRRVETPVLP PVLVPRHSEY NPQLSLLAKF RSASLHSEPL MPHNATYPDS FQQSLGPAPP SSPGHVFPQS PCPTSYPQSP GSPSESDSPY QHSDFRPVCY EEPLHWCSVA YYELNNRVGE TFQASSRSVL IDGFTDPSNN RNRFCLGLLS NVNRNSTIEN TRRHIGKGVH LYYVGGEVYA ECVSDSSIFV QSRNCNYQHG FHPATVCKIP SGCSLKVFNN QLFAQLLAQL LAQSVHHGFE VVYELTKMCT IRMSFVKGWG AEYHRQDVTS TPCWIEIHLH GPLQWLDKVL TQMGSPHNPI SSVS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4. ALK-2 binds TGF-beta, activin and BMP.

Gene References into Functions

Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MIS receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression. PMID:16687449
Expression of BMP receptors Ib and II, and Smad 8 was downregulated in lungs but not kidneys of MCT-treated rats. PMID:17347486

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Dwarfin/SMAD family

Database Links

UNIGENE: Rn.10862

KEGG: rno:85435

STRING: 10116.ENSRNOP00000000102

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