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Recombinant Rat Mitogen-activated protein kinase 10 (Mapk10)

Recombinant Rat Mitogen-activated protein kinase 10 (Mapk10)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mapk10

Uniprot NO.

P49187

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-464

Target Protein Sequence

MSLHFLYYCS EPTLDVKIAF CQGFDKHVDV SSVVKHYNMS KSKVDNQFYS VEVGDSTFTV LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLSAIKHL HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock. Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1.

Gene References into Functions

A novel interaction between KLF9 and JNK3, contributes to axon growth suppression and inhibition of axon regeneration. PMID:28871032
Results suggest that cilostazol could protect hippocampal neurons and ameliorate the impairment of learning/memory abilities and locomotor/exploratory activities in ischemic stroke via a PI3K-Akt1/JNK3/caspase-3 dependent mechanism PMID:27769787
In hippocampal neurons, BDNF up-regulates JIP3 expression via CREB activation. PMID:26303065
JNK3 phosphorylatesrRat brain mitochondrial VDAC channel, which leads to the channel closure. PMID:25721670
Rotenone induces dopamine neuron death through a series of sequential events including microtubule destabilization, JNK3 activation, VMAT2 inhibition, accumulation of cytosolic dopamine, and generation of ROS. PMID:25496994
JNK3 participates in an adaptive response to neuronal hyperexcitation by impeding secretory trafficking at the Golgi complex. PMID:23838184
Akt1 activation is involved in the neuroprotection of HSP72 against ischemic brain injury via suppressing JNK3 signaling pathway, providing a new experimental foundation for stroke therapy. PMID:22386689
Data show that JNK3 silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression. PMID:22563476
Data suggest that JNK isoforms are involved in differential regulation of neuronal death and regeneration, and that JNK3 appears to be required for regeneration and survival in the case of an environment permissive for regeneration. PMID:21468718
K252a plays a neuroprotective role in ischemic injury via inhibition of the JNK pathway (MKK7 AND JNK3) PMID:15680699
interaction of free arrestins with JNK3 and Mdm2 and their ability to regulate subcellular localization of these proteins may play an important role in the survival of photoreceptors and other neurons PMID:16737965
These findings strongly suggest that Cdc42 serves as an upstream activator and modulates JNK-mediated apoptosis machinery in vivo, which ultimately results in neuronal apoptosis via nuclear and non-nuclear pathways. PMID:17161586
JNK3 apoptotic signaling pathway is attentuated by stimulating GABA receptors via inhibiting the increased assembly of the GluR6-PSD-95-MLK3 signaling module in cerebral ischemia PMID:18307989
A prominent role for JNK3 is the maintenance of cellular differentiation in glia cells; expression of JNK3 protein and mRNA are increased in growth arrested C6 glioma cells. PMID:18513991
In a neonatal rat model of pneumococcal meningitis, JNK3 (but not JNK1 or JNK2) is activated in the hippocampus during the acute phase of infection and may be involved in processes unrelated to apoptosis in this disease. PMID:18703144