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Recombinant Rat Microtubule-actin cross-linking factor 1 (Macf1), partial

Recombinant Rat Microtubule-actin cross-linking factor 1 (Macf1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Macf1

Uniprot NO.

D3ZHV2

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-5430

Target Protein Sequence

MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK ALYNQYIHFK ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH VEEEWGKLIV EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDEKYY QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP STLTTTHLKA EPLNKTTHSS STSWFRKPMT RTELVAISSS EDEGSLRFVY ELLSWVEEMQ MKLERAEWGN DLPSVELQWE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF HTSYVETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSKAT AELIWLNGKE EEELACDWSD SNPNISAKKA YFSELTMELE GKQDVFRSLQ DTAELLSLEN HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HIKENAAYFQ FFSDARDLES FLRNLQDSIK RKYTCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR TKWKVISPTG NEAMVPSVCL LIPPPNTEAI DVASRVEQSY QKVMALWHQL HINTKSLISW NYLRKDIDAV QTWNLEKLRS SAPGECHQVM KNLQAHYEDF LQDSHDSALF SVADRLRIEE EVEACKTHFQ QLMESMENED KEETLAKVYI SELKNIRLRL EECEQRLLKQ IQSSASSKTD RDARQDVALR IAEQEHVQED LKHLRSDLDA VSVKCTTFLQ QSPSGSSATT LRSELNLMVE KMDHVYGLSI VCLNKLKTID VIVRSIQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL QHWLSDVKDK NSVFSVLDEE ISKAKAVAEQ LHHRAAEPNL DLERYQEKGS QLQERWHRVI AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM MKPGQAEDSR VLSEQLSQQT ELFAEIERNQ TKLDQCQKLS QQYSTTVKDY ELQLMTYKAF VESQQKSPGK RRRMISSSDA ITQEFMDLRT RYTALVTLTT QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST LARNTQGTTT SSRTSASTDI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS EREKEQISEQ LCALNKTYHD LCDGSANQLQ QLQSELAQQT EQKTLQKQQD TCHKKLEDLR SWVRQAERAL ERHRGRASQQ ELSALQQNQS DLKDLQGDIQ NHSTSFATAV KDIEGFLEEN QNKLSPQELT ALREKLYQAK EQYEGLQDRT REAQKELEEA VTSALQQETE KSKAATELAE NRRKIDALLD WVTSVGSSDR QPQTSLPGTE QFSGACLEKQ TLDATDGCVD VNQVPEKLDR QYELMKARHQ ELLSQQQNFI VATQSAQSFL DQHSHNLTPE ERQMLQEKLG ELKEQYAASL AQSEAKLRQT QTLRDELQKF LQDHREFENW LERSENELDG MHTGGSSPEA LNSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLETENNFE EGQEPSPTRN LVNEKLKDAT ERYTTLHSKC TRLGSHLNML LGQYQQFQSS ADSLQAWMLT CEASVEKLLS DTVASDPGIL QQQLATTKQL QEELAEHQVP VEKLQKAAHD LMDIEGEPSL DCTPIRETTE SIFSRFQSLS CSLAERSALL QKAIAQSQSV QESMESLLQS MKEVEQNLEG EQVAALSSGL IQEALANNMK LKQDIARQKS SLEATREMVT RFMETADGNS AAVLQDRLAE LSQRFHRLQL QQQEKESGLK KLLPQAETFE QLSSKLQQFV EHKNRLLASG NQPDQDIAHF SQHIQELTLE MEDQKENLGT LEHLVTALGS CGFALDLSQH QEKIQNLKKD FTELQKTVQE REKDASNCQE QLDEFRKLIR TFQKWLKETE GNVPPAETFV SAKELEKQIE HLKGLLDDWA GKGVLVEEIN TKGTALESLI MDITAPDSQA KTGSVLPSVG SSVGSVNGYH TCKDLTEIQC DMSDVNSKYD KLGDALRERQ ESLQTVLSRM EEVQKEASSV LQWLESKEEV LKGMDASLSP TKTETVKAQA ESNKAFLAEL EQNSPKIQKV KEALAGLLEA YPNSQEAENW RKMQEDLNSR WEKATEVTVA RQKQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK QQVQFMLKEF EARRQQHEQL TEAAQGILTG PGDVSPSASQ VHKDLQSISQ KWVELTDKLN SRSTQIDQAI VKSTQYQDLL QDLSEKVKAV GQRLSGQSAI STQPDAVKQQ LEETSEIRSD LGQLDDEMKE AQTLCQELSL LIGEQYLKDE LKKRLETVAL PLQGLEDLAA DRMNRLQAAL ASTQQFQQMF DELRTWLDEK QSQQAKNCPI SAKLERLQSQ LQENEEFQKN LNQHSGSYEV IVAEGESLLL SVPPGEEKKT LQNQLVELKS HWEDLNKKTV DRQSRLKDCM QKAQKYQWHV EDLVPWIKDC KSKMSELQVT LDPVQLESSL LRSKAMLNEA EKRRSLLEIL NSAADILINS SEIDEDEIRD EKAGLNQNMD AITEELQAKT GSLEEMTQRL KEFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL KAQREVLQAL DPQVDYLRDF TRGLVEDAPD GSDASPLVHQ AELAQQEFLE VKQRVNSSCL TMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDI RLFLNKIQAL RLDIEDSEAE CRKMLEEEGT LDLLGLKREL EALNKQCGKL TERGKARQEQ LELTLGRVED FYSKLKALND AATAAEEGEA LQWIVGTEVD VINQQLADFK MFQKEQVDPL QVKLQQVNGL GQGLIQSAGK TCDVQGLEHD MEEVNTRWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLTDTEELI ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQAAEL ADREKITGQL ESLECRWTEL LSKAAARQKQ LEDILVLAKQ FHETAEPISD FLSVTEKKLA NSEPVGTQTA KIHQQIIRHK ALEEEIENHA ADVQQAVKIG QSLSSLICPA EQGIMSEKLD SLQARYSEIQ DRCCRKASLL EQALFNARLF GEDEVEVLNW LAEVEDKLSA VFVKDYRQDV LQKQHADHLA LNEEIINRKK NVDQAIKNGQ ALLKQTTGEE VLLIQEKLDG IKTRYADITV TSSKALRTLE QARQLATKFH STYEELTGWL REVEEELAAS GGQSPTGEQI PQFQQRQKEL KKEVMEHRLV LDTVNEVSHA LLELVPWRAR EGLDKLVSDA NEQYKLVSDT VGQRVDEIDA AIQRSQQYEQ AADAELAWVA ETKRKLMALG PIRLEQDQTT AQLQVQKAFS IDIIRHKDSM DELFSHRGEI FSTCGEEQKA VLQEKTECLI QQYEAVSLLN SERYARLERA QVLVNQFWET YEELSPWAEE TLALIAQLPP PAVDHEQLRQ QQEEMRQLRE SIAEHKPHID KILKIGPQLK ELNPEEGKMV EEKYQKAENM YAQIKDEVRQ RALALDEAVS QSAQIAEFHD KIEPMLETLE NLSSRLRMPP LIPAEVDKIR ECISDNKSAT MELEKLQPSF EALKRRGEEL IGRSQGADKD LAAKEIQDKL DQMVFFWEDI KARSEEREIK FLDVLELAEK FWYDMAALLT TIKDTQEIVH DLESPGIDPS IIKQQVEAAE TIKEETDGLH EELEFIRILG ADLIFACGET EKPEVKKSID EMNNAWENLN RTWKERLEKL EDAMQAAVQY QDTLQAMFDW LDNTVIRLCT MPPVGTDLNT VKDQLNEMKE FKVEVYQQQI EMEKLNHQGE LMLKKATDET DRDIIREPLT ELKHLWENLG EKIAHRQHKL EGALLALGQF QHALEELMGW LTHTEELLDA QRPISGDPKV IEVELAKHHV LKNDVLAHQA TVETVNKAGN ELLESSAGDD ASSLRSRLET MNQCWESVLQ KTEEREQQLQ STLQQAQGFH SEIEEFLLEL NRMESQLSAS KPTGGLPETA REQLDAHMEL HSQLRAKEEI YNQLLDKGRL MLLSRGDSGS GSKTEQSVAL LEQKWHVVSS KVEERKSKLE EALSLATEFQ NSLQEFINWL TLAEQSLNIA SPPSLILNTV LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ LKFLSQKQDV VLIKNLLVSV QSRWEKVVQR SIERGRSLDD ARKRAKQFHE AWKKLIDWLE DAESHLDSEL EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY DTTIRTGRAL KEKTLLADDA QKLDNLLGEV RDKWDTVCGK SVERQHKLEE ALLFSGQFMD ALQALVDWLY KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ KELGKRTGTV QVLKRSGREL IESSRDDTTW VKGQLQELST RWDTVCKLSV SKQSRLEQAL KQAEEFRDTV HMLLEWLSEA EQTLRFRGAL PDDTEALQSL IDTHKEFMKK VEEKRVDVNA AVAMGEVILA VCHPDCITTI KHWITIIRAR FEEVLTWAKQ HQQRLETALS ELVANAELLE ELLAWIQWAE TTLIQRDQEP IPQNIDRVKA LITEHQSFME EMTRKQPDVD RVTKTYKRKN IEPTHAPFIE KSRSGSRKSL NQPTPPPMPI LSQSEAKNPR INQLSARWQQ VWLLALERQR KLNDALDRLE ELKEFANFDF DVWRKKYMRW MNHKKSRVMD FFRRIDKDQD GKITRQEFID GILASKFPTT KLEMTAVADI FDRDGDGYID YYEFVAALHP NKDAYRPTTD ADKIEDEVTR QVAQCKCAKR FQVEQIGENK YRFGDSQQLR LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RARGRTNIEL REKFILPEGA SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA SQSNHSCTSM PSSPATPASG TKVISSTGSK LKRPTPTFHS SRTSLAGDTS NSSSPASTGA KTNRADPKKS ASRPGSRAGS RAGSRASSRR GSDASDFDLL ETQSACSDTS ESSAAGGQGS SRRGLTKPSK IPTMSKKTTT ASPRTPCPKR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.

Gene References into Functions

Strong Macf1 expression was observed in the inner plexiform layer and granular cell layer where it was colocalizied with Thy-1 staining. PMID:22496866

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane. Membrane.

Protein Families

Plakin or cytolinker family

Database Links

UNIGENE: Rn.213155

STRING: 10116.ENSRNOP00000041065

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