Recombinant Rat Metalloreductase STEAP3 (Steap3), partial

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression.