Recombinant Rat Metabotropic glutamate receptor 4 (Grm4), partial

1. This study investigated the role of mGluR4 in modulating two distinct forms of waiting impulsivity and its putative interaction with D2 receptors in modulating motor impulsivity on the five-choice serial reaction time task. The main findings indicate a prominent role of mGluR4 in modulating motor, and to some extent choice, impulsivity as well as aspects of visual attention. PMID:28487067
2. activation of mGluR4 prevents oxidative stress-induced NSC death and apoptotic-associated protein activities with involvement of inhibiting the JNK and p38 pathways in cell culture. PMID:26176363
3. mGluR4 promotes the proliferation of rat neural progenitor cells and cyclin D1 expression through activation of ERK1/2 signaling pathways in vitro. PMID:23374450
4. mGluR4 inhibition of presynaptic Ca2+ influx employs a newly defined signalling pathway, notably that involving the activation of phospholipase C and ultimately protein kinase C PMID:22570379
5. native mGluR4 interacts with several exocytosis proteins such as Munc18-1, synapsins, and syntaxin. PMID:22528491
6. Selective activation of mGluR4 with L(+)-2-amino-4-phosphnobytyric acid decreased the probability of glutamate release from the mossy fiber terminals synapsing onto stratum lacunosum-moleculare interneurons. PMID:20824730
7. these results suggest the alteration of the spinal mGluR4 expression that contributes to the development of neuropathic pain. PMID:21358553
8. The increased expression of mGluR4 is an important process in the pathophysiological of DBI and its specific agonist L-AP4 can provide a remarkable neuroprotection against DBI but also in the motor and cognitive performance. PMID:14592619
9. mGluR4 is potentiated by N-phenyl-7-(hydroxylimino)cyclopropa[b]chromen-1a-carboxamide (PHCCC) PMID:14593202
10. results indicate that alpha- and F cells express functional mGluR4, and its stimulation inhibits secretion of glucagon through an inhibitory cAMP cascade PMID:15047615
11. Retinal terminals are the major contributors to the mGluR4a immunoreactivity observed in the superior collicular circuitry. PMID:15730868
12. Striatonigral/striato-entopeduncular MSNs are likely to be the largest source of type 2 mGluR4-immunopositive axon terminals in the neostriatum. All ChAT-immunopositive and 41% of NK1 receptor-positive dendrites were heavily associated with type 2 mGluR4. PMID:17177262
13. PHCCC is an allosteric modulator of mGlu(4) receptor, without direct agonist activity. PMID:18593581

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UNIGENE: Rn.89046

KEGG: rno:24417

STRING: 10116.ENSRNOP00000060812