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Recombinant Rat Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Magi3), partial

Recombinant Rat Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Magi3), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Magi3

Purity

>85% (SDS-PAGE)

Target Names

Magi3

Uniprot NO.

Q9JK71

Alternative Names

Magi3; SliprMembrane-associated guanylate kinase; WW and PDZ domain-containing protein 3; Membrane-associated guanylate kinase inverted 3; MAGI-3; Scaffolding-like protein

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1470

Target Protein Sequence

MSKTLKKKKH WLSKVQECAV SWAGPPGDLG AEIRGGAERG EFPYLGRLRD EPGGGGGTCC VVSGKAPSPG DVLLEVNGTP VSGLTNRDTL AVIRHFREPI RLKTVKPGKV INKDLRHYLS LQFQKGSIDH KLQQVIRDNL YLITIPCTTR APRDGEVPGV DYNFISVEQF KALEESGALL ESGTYDGNFY GTPKPPAEPS PFQPDPVDQV LFDNEFDTES QRKRTTSVSK MERMDSSLPE EEEDEDKEAV NGSGSMETRE MHSESSDCWM KTVPSYNQTN RSMDFRNYMM RDENLEPLPK NWEMAYTDTG TIYFIDHNTK TTTWLDPRLC KKAKAPEDCE DGELPYGWEK IEDPQYGTYY VDHLNQKTQF ENPVEEAKRK KQIGQAETHS AKTDVERAHF TRDPSQLKGV LVRASLKKST MGFGFTIIGG DRPDEFLQVK NVLKDGPAAQ DGKMAPGDVI VDINGNCVLG HTHADVVQMF QLVPVNQYVN LTLCRGYALP DDSEDPVVDI VAATPVINGQ SLAKGEACMS TQDFKLGAMV LDQNGKSGKL LSSDRLNGPS DSNEQRASLA SSGSSQPELV TIPLVKGPKG FGFAIADSPT GQKVKMILDS QWCQGLQKGD IIKEIYHQNV QNLTHLQVVE VLKQFPVGAD VPLLILRGGP CSPTKTAKMK TDTKETSGSL ETINEPTPQP MPFPPSIIRS GSPKLDPSEV YLKSKTLYED KPPNTKDLDV FLRKQESGFG FRVLGGDGPD QSIYIGAIIP LGAAEKDGRL RAADELMCID GIPVKGKSHK QVLDLMTTAA RNGHVLLTVR RKIFYGEKQP EDESPQAFSQ SGSPRLNRTE LPTRSAPQES YDVILQRKEN EGFGFVILTS KSKPPPGVIP HKIGRVIDGS PADRCGRLKV GDHISAVNGQ SIVDLSHDNI VQLIKDAGVT VTLTVVAEEE HHGPPSGTNS ARQSPALQHR PMGQAQATHI PGDRTALEGE VGKDVCSSYR HSWSDHKHLA QPDTAVISVV GSRHSQSLGC YPVELERGPR GFGFSLRGGK EYNMGLFILR LAEDGPAIKD GRIHVGDQIV EINGEPTQGI THTRAIELIQ AGGNKVLLLL RPGTGLIPDH GDWDIYSPSS SNVIYDEQPP PLPSSHSAAT FEESHVPVTE DSLIRVQTCE KAEELKDTVQ EKKSTLNGSQ PEMKYQSIQK NVSKKDPSRS HGHGDKNLLK GENGVTRRGR SASPKKSVNR HSEEHLEKIP RPLRSDPKGK SRDRSLSPRK GENKGQVTIK AGSGQDPCRK DRGRSSSPRK QQKIGGNSLS NTEGKLSEAG SRRAAGLSSD SPEQLPEGKE KSGVSRKDLK LSQLGKNRTR SPEKRSSKVD EASLPSKKTS DTASRVVSEK EKGRKPGTGE RSRDKTGESV QTSAKPLTQE AGEKMALSKA SEVTDRGKER AGGAPESSSP VKKAPITPGP WRVPRANKVT GTAGMADKQL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Subcellular Location

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions.

Protein Families

MAGUK family

Database Links

UNIGENE: Rn.228785

KEGG: rno:245903

STRING: 10116.ENSRNOP00000026952

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