Recombinant Rat Laminin subunit beta-2 (Lamb2), partial

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Lamb2
Uniprot NO.
Alternative Names
Lamb2; Laminin subunit beta-2; Laminin chain B3; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta; S-LAM beta
Species
Rattus norvegicus (Rat)
Source
Yeast
Expression Region
36-1801
Target Protein Sequence
QVPSL DVPGCSRGSC YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH LIMTFKTFRP AAMLVERSAD FGRTWRVYRY FSYDCGADFP GIPLAPPRRW DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC ECNGHSHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE LCRPFFYRDP TKDMRDPAAC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT RCQQCRDGFF GLSASNPRGC QRCQCNSRGT VPGGTPCDSS SGTCFCKRLV TGDGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCPCRPHM IGRRCEQVQP GYFRPFLDHL TWEAEGAHGQ VLEVVERLVT NRETPSWTGV GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELVVQRPGP VSAHSPCGHV LPRDDRIQGM LHPNTRVLVF PRPVCLEPGL SYKLKLKLTG TGGRAHPETP YSGSGILIDS LVLQPHVLML EMFSGGDAAA LERRTTFERY RCHEEGLMPS KTPLSEACVP LLISASSLVY NGALPCQCDP QGSLSSECNP HGGQCRCKPG VVGRRCDACA TGYYGFGPAG CQACQCSPDG ALSALCEGTS GQCLCRTGAF GLRCDHCQRG QWGFPNCRPC VCNGRADECD AHTGACLGCR DYTGGEHCER CIAGFHGDPR LPYGGQCRPC PCPEGPGSQR HFATSCHRDG YSQQIVCHCR AGYTGLRCEA CAPGHFGDPS KPGGRCQLCE CSGNIDPTDP GACDPHTGQC LRCLHHTEGP HCGHCKPGFH GQAARQSCHR CTCNLLGTDP QRCPSTDLCH CDPSTGQCPC LPHVQGLSCD RCAPNFWNFT SGRGCQPCAC HPSRARGPTC NEFTGQCHCH AGFGGRTCSE CQELHWGDPG LQCRACDCDP RGIDKPQCHR STGHCSCRPG VSGVRCDQCA RGFSGVFPAC HPCHACFGDW DRVVQDLAAR TRRLEQWAQE LQQTGVLGAF ESSFLNLQGK LGMVQAIVAA RNTSAASTAK LVEATEGLRH EIGKTTERLT QLEAELTDVQ DENFNANHAL SGLERDGLAL NLTLRQLDQH LDILKHSNFL GAYDSIRHAH SQSTEAERRA NASTFAIPSP VSNSADTRRR AEVLMGAQRE NFNRQHLANQ QALGRLSTHT HTLSLTGVNE LVCGAPGDAP CATSPCGGAG CRDEDGQPRC GGLGCSGAAA TADLALGRAR HTQAELQRAL VEGGGILSRV SETRRQAEEA QQRAQAALDK ANASRGQVEQ ANQELRELIQ NVKDFLSQEG ADPDSIEMVA TRVLDISIPA SPEQIQRLAS EIAERVRSLA DVDTILAHTM GDVRRAEQLL QDAQRARSRA EGERQKAETV QAALEEAQRA QGAAQGAIRG AVVDTKNTEQ TLQQVQERMA GTEQSLNSAS ERARQLHALL EALKLKRAGN SLAASTAEET AGSAQSRARE AEKQLREQVG DQYQTVRALA ERKAEGVLAA QARAEQLRDE ARGLLQAAQD KLQRLQELEG TYEENERELE VKAAQLDGLE ARMRSVLQAI NLQVQIYNTC Q
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Gene References into Functions
  1. Crystallographic analysis of the LAMB2 short arm reveals how the LF domain is inserted into a regular array of LE domains. PMID:27425256
  2. Together, these studies provide evidence for regulation of Lamb2 translation by IMP2, an RNA binding protein that targets Lamb2 mRNA to the actin cytoskeleton. PMID:22513850
  3. R246Q mutation causes nephrotic syndrome by impairing secretion of laminin-521 from podocytes into the glomerular basement membrane (GBM). PMID:21511833

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Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity
Found in the basement membranes (major component). S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
Database Links

UNIGENE: Rn.774

KEGG: rno:25473

STRING: 10116.ENSRNOP00000065052

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