Recombinant Rat L-asparaginase (Asrgl1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Asrgl1

Purity

>85% (SDS-PAGE)

Target Names

Asrgl1

Uniprot NO.

Q8VI04

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-190

Target Protein Sequence

MATARPSSCG RDSVPATPRA SIDVSLVVVV HGGGASNISP GRKELVSEGI AKAATEGYNI LKAGGSAVDA VEGAVTMLEN DPEFNAGYGS VLNADGDIEM DASIMDGKDL SAGAVSAVRC IANPVKLARL VMEKTPHCFL TGRGAEKFAA DMGIPQTPAE KLITERTKKH LEKEKLEKGA QKADCPKNSG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Has both L-asparaginase and beta-aspartyl peptidase activity. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.

Gene References into Functions

A novel asparaginase-like protein (ALP) of spermatozoa was cloned from rat and human testis cDNA libraries on the basis of reactivity with antibodies produced after vasectomy PMID:11984834
Gliap is abundant in liver and testis and in brain Gliap is exclusively expressed in astrocytes and present in structures resembling glial endfeet. This suggests Gliap is involved in astroglial production of the neuroactive amino acid L-aspartate PMID:12753071

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Subcellular Location

Cytoplasm. Note=Midpiece of sperm tail.

Protein Families

Ntn-hydrolase family

Tissue Specificity

Present in testis, brain, liver, kidney, heart and skeletal muscle. In brain, specifically present in the astrocytic lineage. Present in sperm (at protein level).

Database Links

UNIGENE: Rn.22774

KEGG: rno:246307

STRING: 10116.ENSRNOP00000027459

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