Recombinant Rat Krueppel-like factor 2 (Klf2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Klf2

Purity

>85% (SDS-PAGE)

Target Names

Klf2

Uniprot NO.

Q9ET58

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-351

Target Protein Sequence

MALSEPILPS FATFASPCER GLQERWPRNE PEAGSTDEDL NSVLDFILSM GLDGLGAENP PEPPPQPPPP AFYYPEPGAP PPYGTPAAGL GTELLRPDLD APQGPALHGR FLLAPPGRLV KAEPPEVDGG GYGCAAGLAR GPRGLKLEGA LGATGACMRG PAGRPPPPSD TPPLSPDGPP RLPAPGPRNP FPPPFGPGPS FGGPGPALHY GPPAPGAFGL FDDAAAALGL APPATRGLLT PPSSPLELLE AKPKRGRRSW PRKRAATHTC SYTNCGKTYT KSSHLKAHLR THTGEKPYHC NWDGCGWKFA RSDELTRHYR KHTGHRPFQC HLCDRAFSRS DHLALHMKRH M
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.

Gene References into Functions

KLF2 was remarkably downregulated in bleomycin-treated rats, both in mRNA and protein levels. Additionally, overexpression of KLF2 attenuated the destruction of the alveolar space and pulmonary interstitial collagen hyperplasia. PMID:29079188
Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis PMID:27855271
Cirrhotic rats treated with simvastatin showed hepatic up regulation in KLF2 protein and reduction in liver fibrosis. PMID:25500203
Upregulation of hepatic endothelial KLF2-derived transcriptional programs by statins confers vasoprotection and stellate cells deactivation. PMID:22989565
The expression of KLF2 is significantly up-regulated in chronic obstructive pulmonary disease. PMID:22737924
results provide evidence for the first time that lung kruppel like factor is down-regulated in the later stages of lung development, may impair lung development and maturation, resulting in pulmonary hypoplasia in the nitrofen CDH model. PMID:21053160
LKLF gene is not defective in diabetic prone BB rats and its expression is not compromised by mutation. (Klf2) PMID:15033788