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Recombinant Rat Kinesin heavy chain isoform 5A (Kif5a), partial

Recombinant Rat Kinesin heavy chain isoform 5A (Kif5a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Kif5a

Purity

>85% (SDS-PAGE)

Target Names

Kif5a

Uniprot NO.

Q6QLM7

Alternative Names

Kif5aKinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; NKHC

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-1027

Target Protein Sequence

AETNNECSI KVLCRFRPLN QAEILRGDKF IPIFQGDDSV IIGGKPYVFD RVFPPNTTQE QVYHACAMQI VKDVLAGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIARDIFNHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVT KTNLSVHEDK NRVPFVRGCT ERFVSSPEEI LDVIDEGKSN RHVAVTNMNE HSSRSHSIFL INIKQENIET EQKLSGKLYL ADLAGSEKVS KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKSYVPYR DSKMTRILQD SLGGNCRTTM FICCSPSSYN DAETKSTLMF GQRAKTIKNT ASVNLELTAE QWKKKYEKEK EKTKAQKETI AKLEAELSRW RNGENVPETE RLAGEDSALA AEICEETPVN DNSSIVVRIA PEERQKYEEE IRRLYKQLDD KDDEINQQSQ LIEKLKQQML DQEELLVSTR GDNEKVQREL SHLQSENDAA KEEVKEVLQA LEELAVNYDQ KSQEVEEKSQ QNQLLVDELS QKVATMLSLE SEPQRLQEVS GHQRKRIAEV LNGLMKDLSE FSVIVGNGEI KLPVEISGAI EEEFTVARLY ISKIKSEVKS VVKRCRQLEN LQVECHRKME VTGRELSSCQ LLISQHEAKI RSLTEYMQTV ELKKRHLEES YDSLSDELAK LQAQETVHEV ALKDKEPDTQ DAEEVKKALE LQMENHREAH HRQLARLRDE INEKQKTIDE LKDLDQKLQL ELEKLQADYE RLKNEENEKS AKLQELTFLY ERHEQSKQDL KGLEETVARE LQTLHNLRKL FVQDVTTRVK KSAEMEPEDS GGIHSQKQKI SFLENNLEQL TEVHKQLVRD NADLRCELPK LEKRLRATAE RVKALEGALK EAKEGAMKDK RRYQQEVDRI KEAVRYKSSG KRGHSAQIAK PVRPGHYPAS SPTNPYGTRS PECISYTNNL FQNYQNLHLQ AAPSSTSDVY FASNGATSVA PLASYQKANT DNGNATDIND NRSDLPCGYE AEDPAKLFPL HQETAAS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.

Gene References into Functions

The results of this study showed that Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5 PMID:22539840
kinesin-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migration when the neuron reaches its destination. PMID:21411631

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Subcellular Location

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Perikaryon. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region.

Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily

Tissue Specificity

Expressed in brain.

Database Links

UNIGENE: Rn.63144

KEGG: rno:314906

STRING: 10116.ENSRNOP00000007721

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