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Recombinant Rat Isocitrate dehydrogenase [NADP], mitochondrial (Idh2)

Recombinant Rat Isocitrate dehydrogenase [NADP], mitochondrial (Idh2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Idh2

Uniprot NO.

P56574

Alternative Names

Idh2; Isocitrate dehydrogenase [NADP]; mitochondrial; IDH; EC 1.1.1.42; ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

40-452

Target Protein Sequence

A EKRIKVEKPV VEMDGDEMTR IIWQFIKEKL ILPHVDVQLK YFDLGLPNRD QTNDQVTIDS ALATQKYSVA VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGTVFRE PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVVDRAG MFKLVFTPKD GSGAKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYSI QKKWPLYLST KNTIMKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT VTRHYREHQK GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQTLEK VCVQTVESGA MTKDLAGCIH GLSNVKLNEH FLNTTDFLDT IKSNLDRALG KQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene References into Functions

Sppression of isocitrate dehydrogenase [NADP] mitochondrial expression by siRNA induces apoptosis and hypertrophy of cultured cardiomyocytes. PMID:24296260
IDH2 mutations are closely associated with glioma progression and chemo-resistance. PMID:22309944
IDH2(R172G) mutation in gliomas may give a benefit to traditional chemotherapy of this cancer. PMID:21641335

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Subcellular Location

Mitochondrion.

Protein Families

Isocitrate and isopropylmalate dehydrogenases family

Database Links

UNIGENE: Rn.3490

KEGG: rno:361596

STRING: 10116.ENSRNOP00000019059

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