Recombinant Rat Interleukin-4 (Il4)

1. age-related decrease in IL-4 expression exacerbated surgery-induced cognitive deficits and exaggerated the neuroinflammatory responses PMID:28414034
2. IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response PMID:26951461
3. Formoterol synergizes with des-ciclesonide to inhibit IL-4 expression in IgE/antigen-induced mast cells by inhibiting JNK activation. PMID:26003274
4. CaSR activation promoted T-cell apoptosis and the secretion of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-4. PMID:25256599
5. IL-4 was found to augment the mRNA expression of ICAM-1. PMID:23904363
6. IL-4 has a modulatory effect on the enzymatic compartment of the antioxidant defense system in the brain of rats. PMID:24319732
7. IL-4 promoted the activation of effector cells to mediate rejection and did not support alloantigen-specific Treg that could transfer specific tolerance. PMID:24139939
8. The level of IL-4 is elevated in masseter muscle of both sexes following chemically induced inflammation. PMID:20969918
9. Treatment with intranasal interferon gamma can inhibit production of IL4 and IL5 in allergic rhinitis. PMID:18510219
10. IL4 in bronchoalveolar lavage fluid of allergic rhinitis rats was elevated. PMID:16229173
11. endogenous expression of antiinflammatory cytokine IL-4 regulates the extent of acute macrophage activation and confines the ensuing secondary cavity formation after spinal cord trauma PMID:20623539
12. passive rats exposed to emotional stress were characterized by a decreased blood levels of TNF alpha and IL-4 as compared to behaviorally passive controls and behaviorally active animals exposed to stress. PMID:20120734
13. A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against type 1 diabetes in BioBreeding rats. PMID:12004164
14. Gene transfer of IL-4 may represent a potential therapeutic approach to induce tolerance to splenic allografts. PMID:15251393
15. IL-4 appears to be an important Th2 cytokine involved in the induction of the L-arginine/iNOS pathway in eosinophils PMID:15826818
16. synthesis and release from mast cells mediated by Mycoplasma pneumoniae P1 adhesin PMID:16169702
17. HSV-mediated expression of IL-4 effectively reduces the behavioral manifestations of neuropathic pain, and reverses some of the biochemical and histologic correlates of neuropathic pain at the spinal level. PMID:16503976
18. Data show that islets of non-diabetic BB rats become positive to both IL-1beta and IL-4 very early on, and that production of these interleukins together with the expression of CD4 and CD25 are predictive for type 1 diabetes onset in non-diabetic BB rats. PMID:16972262
19. These data suggest that IL-4 may provide a significant immunomodulatory signal which can protect against microglia-mediated neurotoxicity by suppressing the production and release of free radicals. PMID:17018025
20. We conclude that IL-4 exerts its anti-inflammatory effects in a limited and target-specific manner, which is delicately regulated by the cellular microenvironment. T PMID:17442043
21. Our data demonstrate, for the first time, the neuroprotective effect of IL-4 through cAMP/PKA pathway in thapsigargin-induced photoreceptor cell death. PMID:19235892

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UNIGENE: Rn.108255

KEGG: rno:287287

STRING: 10116.ENSRNOP00000010029