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Recombinant Rat Interleukin-22 receptor subunit alpha-2 (Il22ra2)

Recombinant Rat Interleukin-22 receptor subunit alpha-2 (Il22ra2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Il22ra2

Purity

>85% (SDS-PAGE)

Target Names

Il22ra2

Uniprot NO.

Q7TNI4

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

20-229

Target Protein Sequence

T QPAHVSLKPQ KVQFQSRNFH NILHWQPGNS LTSNGSVYFV QYKTYGQGQW KDKNDCWGTT ALFCDLTKET LDPYEPYYGR VMMAWAGSYS EWTRTPRFTP WWETKLDPPV VTITRVNASL RVRLRPPELP HRNQTGKNTS MENYYNLVYR VSIINNSLEK EQKAYEGTQR AVEIQGLTPH CSYCVVAEMY QPMFDRRSPR SKERCVQIP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.

Gene References into Functions

this study shows that rats with genetic IL-22BP deficiency (Il22ra2-/-) display exacerbated psoriasis that is associated with enhanced expression of IL-22-inducible antimicrobial peptides PMID:28356382
IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID:26329427
Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID:21041731

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Subcellular Location

Secreted.

Protein Families

Type II cytokine receptor family

Database Links

UNIGENE: Rn.13127

KEGG: rno:444986

STRING: 10116.ENSRNOP00000016354

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